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Title: The use of probiotics versus psyllium husk as a bowel preparation for prostate radiotherapy: a retrospective analysis.
Epworth Authors: Hamilton, Daniel
McKenzie, Dean
Wasiak, Jason
Fenton, Paul
Keywords: Prostate Cancer
Prostate Radiotherapy
Rectal Distension
Bowel Preparation Strategies
Psyllium Husk
Cone Beam Computed Tomography
Clinical Trials and Research Centre, Epworth HealthCare, Victoria, Australia
Epworth Radiation Oncology, Epworth HealthCare, Victoria, Australia
Epworth Prostate Cancer Research Centre, Epworth Healthcare, Richmond, Victoria, Australia
Issue Date: Dec-2015
Publisher: Cambridge University Press
Citation: Journal of Radiotherapy in Practice, 14(4), pp. 378–384.
Abstract: The use of bowel preparation strategies to reduce the degree of rectal distension during prostate radiotherapy is well documented. This retrospective pilot study analysed and compared a probiotic agent against a psyllium-supplemented diet to establish the feasibility of probiotics as a bowel preparation for patients receiving radical radiotherapy for prostate cancer. A retrospective chart review of five patients taking probiotics and five taking psyllium husk (psyllium) during their course of radiotherapy treatment was conducted. On treatment, cone beam computed tomography (CBCT) scans were compared with planning CTs to quantify inter-fractional variation in rectal volume and distension. Forty-five CBCT scans were available in both the psyllium and probiotics groups for analysis. Variation in mean difference in rectal volume from planning (ΔRV), mean rectal cross-section area (CSA) and mean relative cross-section area (CSArel) was significantly increased for the probiotics group compared with the psyllium group (p=0·001, 0·008 and 0·007, respectively). No statistically significant differences in mean ΔRV, CSA and CSArel were detected between the two groups. This retrospective analysis suggests that a probiotics-based bowel preparation that utilises Lactobacillus acidophilus and Bifidobacterium lactis may result in increased rectal volume and CSA variation throughout treatment in comparison with a psyllium-supplemented diet.
DOI: 10.1017/S1460396915000254
ISSN: 1460-3969
Journal Title: Journal of Radiotherapy in Practice
Type: Journal Article
Affiliated Organisations: School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia
Type of Clinical Study or Trial: Retrospective studies
Appears in Collections:Cancer Services
Epworth Prostate Centre
Radiation Oncology
UroRenal, Vascular

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