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Title: Physical inactivity is associated with narrower lumbar intervertebral discs, high fat content of paraspinal muscles and low back pain and disability.
Epworth Authors: O'Sullivan, Richard
Other Authors: Teichtahl, Andrew
Urquhart, Donna
Wang, Yuanyuan
Wluka, Anita
Jones, Graeme
Cicuttini, Flavia
Keywords: MRI Department, Healthcare Imaging Services, Epworth HealthCare, Victoria, Australia
Body Mass Index
Confidence Intervals
Cross-Sectional Area
Statistics, Nonparametric
Magnetic Resonance Imaging
MRI Scans
Odds Ratio
Risk Ratio
Relative Odds
Physical Activity
Motor Activity
Locomotor Activity
Paraspinal Muscles
Deep Muscles of the Back
Intervertebral Disc Disease
Lumbar Disc Disease
Low Back Pain
Lower Back Pain
Intervertebral Disc
Disc, Intervertebral
Body Weight
Zygapophyseal Joint
Facet Joint
Chronic Pain
Pain, Chronic
Issue Date: May-2015
Publisher: BioMed Central
Citation: Arthritis and Research Therapy 2015 May 7;17(1):114
Abstract: INTRODUCTION: Although physical inactivity has been associated with numerous chronic musculoskeletal complaints, few studies have examined its associations with spinal structures. Moreover, previously reported associations between physical activity and low back pain are conflicting. This study examined the associations between physical inactivity and intervertebral disc height, paraspinal fat content and low back pain and disability. METHODS: Seventy-two community-based volunteers not selected for low back pain underwent magnetic resonance imaging (MRI) of their lumbosacral spine (L1 to S1) between 2011 and 2012. Physical activity was assessed between 2005 and 2008 by questionnaire, while low back pain and disability were assessed by the Chronic Pain Grade Scale at the time of MRI. Intervertebral disc height and cross-sectional area and fat content of multifidus and erector spinae were assessed from MRI. RESULTS: Lower physical activity levels were associated with a more narrow average intervertebral disc height (β -0.63 mm, 95% confidence interval (CI) -1.17 mm to -0.08 mm, P = 0.026) after adjusting for age, gender and body mass index (BMI). There were no significant associations between physical activity levels and the cross-sectional area of multifidus or erector spinae. Lower levels of physical activity were associated with an increased risk of high fat content in multifidus (odds ratio (OR) 2.7, 95% CI 1.1 to 6.7, P = 0.04) and high-intensity pain/disability (OR = 5.0, 95% CI 1.5 to 16.4, P = 0.008) after adjustment for age, gender and BMI. CONCLUSIONS: Physical inactivity is associated with narrower intervertebral discs, high fat content of the multifidus and high-intensity low back pain and disability in a dose-dependent manner among community-based adults. Longitudinal studies will help to determine the cause and effect nature of these associations.
DOI: 10.1186/s13075-015-0629-y
PubMed URL:
ISSN: 1478-6354
Journal Title: Arthritis and Research Therapy
Type: Journal Article
Affiliated Organisations: Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, Melbourne, Victoria, Australia
Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
Department of Medicine, Central Clinical School, Monash University, Melbourne, Victoria, 3004, Australia
Menzies Research Institute, Hobart, Tasmania, Australia
Type of Clinical Study or Trial: Prospective Cohort Study
Appears in Collections:Musculoskeletal
Pain Management

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