Please use this identifier to cite or link to this item: http://hdl.handle.net/11434/285
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dc.contributor.authorO'Sullivan, Richarden
dc.contributor.otherTeichtahl, Andrewen
dc.contributor.otherUrquhart, Donnaen
dc.contributor.otherWang, Yuanyuanen
dc.contributor.otherWluka, Anitaen
dc.contributor.otherJones, Graemeen
dc.contributor.otherCicuttini, Flaviaen
dc.date2015en
dc.date.accessioned2015-07-27T22:37:10Zen
dc.date.available2015-07-27T22:37:10Zen
dc.date.issued2015-05en
dc.identifier.citationArthritis and Research Therapy 2015 May 7;17(1):114en
dc.identifier.issn1478-6354en
dc.identifier.urihttp://hdl.handle.net/11434/285en
dc.description.abstractINTRODUCTION: Although physical inactivity has been associated with numerous chronic musculoskeletal complaints, few studies have examined its associations with spinal structures. Moreover, previously reported associations between physical activity and low back pain are conflicting. This study examined the associations between physical inactivity and intervertebral disc height, paraspinal fat content and low back pain and disability. METHODS: Seventy-two community-based volunteers not selected for low back pain underwent magnetic resonance imaging (MRI) of their lumbosacral spine (L1 to S1) between 2011 and 2012. Physical activity was assessed between 2005 and 2008 by questionnaire, while low back pain and disability were assessed by the Chronic Pain Grade Scale at the time of MRI. Intervertebral disc height and cross-sectional area and fat content of multifidus and erector spinae were assessed from MRI. RESULTS: Lower physical activity levels were associated with a more narrow average intervertebral disc height (β -0.63 mm, 95% confidence interval (CI) -1.17 mm to -0.08 mm, P = 0.026) after adjusting for age, gender and body mass index (BMI). There were no significant associations between physical activity levels and the cross-sectional area of multifidus or erector spinae. Lower levels of physical activity were associated with an increased risk of high fat content in multifidus (odds ratio (OR) 2.7, 95% CI 1.1 to 6.7, P = 0.04) and high-intensity pain/disability (OR = 5.0, 95% CI 1.5 to 16.4, P = 0.008) after adjustment for age, gender and BMI. CONCLUSIONS: Physical inactivity is associated with narrower intervertebral discs, high fat content of the multifidus and high-intensity low back pain and disability in a dose-dependent manner among community-based adults. Longitudinal studies will help to determine the cause and effect nature of these associations.en
dc.publisherBioMed Centralen
dc.subjectMRI Department, Healthcare Imaging Services, Epworth HealthCare, Victoria, Australiaen
dc.subjectBody Mass Indexen
dc.subjectConfidence Intervalsen
dc.subjectCross-Sectional Areaen
dc.subjectStatistics, Nonparametricen
dc.subjectMagnetic Resonance Imagingen
dc.subjectMRI Scansen
dc.subjectOdds Ratioen
dc.subjectRisk Ratioen
dc.subjectRelative Oddsen
dc.subjectPhysical Activityen
dc.subjectMotor Activityen
dc.subjectLocomotor Activityen
dc.subjectParaspinal Musclesen
dc.subjectMultifidusen
dc.subjectDeep Muscles of the Backen
dc.subjectIntervertebral Disc Diseaseen
dc.subjectLumbar Disc Diseaseen
dc.subjectLow Back Painen
dc.subjectLower Back Painen
dc.subjectIntervertebral Discen
dc.subjectDisc, Intervertebralen
dc.subjectObesityen
dc.subjectBody Weighten
dc.subjectZygapophyseal Jointen
dc.subjectFacet Jointen
dc.subjectChronic Painen
dc.subjectPain, Chronicen
dc.titlePhysical inactivity is associated with narrower lumbar intervertebral discs, high fat content of paraspinal muscles and low back pain and disability.en
dc.typeJournal Articleen
dc.identifier.doi10.1186/s13075-015-0629-yen
dc.identifier.journaltitleArthritis and Research Therapyen
dc.description.pubmedurihttp://www.ncbi.nlm.nih.gov/pubmed/25947906en
dc.description.affiliatesDepartment of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, Melbourne, Victoria, Australiaen
dc.description.affiliatesBaker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australiaen
dc.description.affiliatesDepartment of Medicine, Central Clinical School, Monash University, Melbourne, Victoria, 3004, Australiaen
dc.description.affiliatesMenzies Research Institute, Hobart, Tasmania, Australiaen
dc.type.studyortrialProspective Cohort Studyen
dc.type.contenttypeTexten
Appears in Collections:Musculoskeletal
Pain Management

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