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Title: Gleason pattern 4: active surveillance no more.
Epworth Authors: Murphy, Declan
Lawrentschuk, Nathan
Other Authors: Sathianathen, Niranjan
Van den Bergh, Roderick
Keywords: Gleason Pattern 4
Gleason Score
Prostate Cancer
Active Surveillance
CaPSURE Database
Epworth Prostate Centre, Epworth Healthcare, Victoria, Australia
UroRenal, Vascular Clinical Institute, Epworth HealthCare, Victoria, Australia
Issue Date: Sep-2015
Publisher: Wiley
Citation: 2016 Jun;117(6):856-7
Abstract: To reduce overtreatment of indolent prostate cancer (PCa), urologists have embraced active surveillance (AS) as a management strategy for low-risk PCa; however, patterns-of-care studies are now showing that AS is also being used for patients with intermediate-risk disease. A contemporary Australian study of 980 men reported that 8.9% of men with intermediate-risk disease were placed on AS, of whom 53.8% had Gleason score (GS) 3+4 PCa and 10.4% had GS 4+3 PCa [1]. The most recent update from the CaPSURE database also reflected this trend in AS, but questions remain about the safety of this practice, particularly as the majority of AS protocols worldwide exclude men with GS 4 PCa, unless their life expectancy is limited.
DOI: 10.1111/bju.13333
PubMed URL:
ISSN: 1464-410X
Journal Title: BJU International
Type: Journal Article
Affiliated Organisations: Division of Cancer Surgery, University of Melbourne, Victoria, Australia
Department of Urology, Royal Melbourne Hospital, Victoria, Australia.
Faculty of Medicine, Monash University, Melbourne, Victoria, Australia.
Departments of Urology and Surgery, Royal Melbourne Hospital, Melbourne, Vic., Australia.
Department of Surgery, The Austin Hospital, Heidelberg, Victoria., Australia.
Olivia Newton-John Cancer Research Institute, Melbourne, Victoria, Australia.
Type of Clinical Study or Trial: Cohort Study
Appears in Collections:Cancer Services
Epworth Prostate Centre
UroRenal, Vascular

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