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http://hdl.handle.net/11434/827| Title: | Words of wisdom re: Chemohormonal therapy in metastatic hormone-sensitive prostate cancer. |
| Epworth Authors: | Murphy, Declan |
| Other Authors: | Zargar, Homayoun |
| Keywords: | Prostate Cancer Metastatic Prostate Cancer Chemohormonal Therapy CHAARTED Protocol Androgen Deprivation Therapy ADT Docetaxel Chemotherapy Survival Rates Australian Prostate Cancer Research Centre, Epworth HealthCare, Victoria, Australia Cancer Services Clinical Institute, Epworth HealthCare, Victoria, Australia |
| Issue Date: | 2016 |
| Publisher: | Elsevier |
| Citation: | Eur Urol. 2016 Mar;69(3):540 |
| Abstract: | Experts’ summary: This landmark study of men with advanced prostate cancer tested the hypothesis that addition of docetaxel chemotherapy (DC) to androgen deprivation therapy (ADT) at the time of treatment initiation would lead to improved overall survival in men with metastatic prostate cancer (CHAARTED trial). A total of 790 men were randomised. At a median follow-up of 29 mo, overall survival was 13.6 mo longer in the ADT + DC group than for ADT alone (57.6 vs 44.0 mo; hazard ratio [HR] 0.61, 95% confidence interval [CI] 0.47–0.80; p < 0.001). Furthermore, among men with high-volume metastatic disease, the median overall survival was 17.0 mo longer in the ADT + DC group than for ADT alone (49.2 vs 32.2 mo; HR 0.60, 95% CI 0.45–0.81; p < 0.001). Overall, the combined treatment was quite well tolerated. |
| Description: | Comment on Chemohormonal 'Therapy in Metastatic Hormone-Sensitive Prostate Cancer.'. Sweeney CJ, Chen YH, Carducci M, et al, N Engl J Med 2015;373:737–46. |
| URI: | http://hdl.handle.net/11434/827 |
| DOI: | doi: 10.1016/j.eururo.2015.12.027 |
| PubMed URL: | https://www.ncbi.nlm.nih.gov/pubmed/26867727 |
| ISSN: | 0302-2838 |
| Journal Title: | European Urology |
| Type: | Comment |
| Affiliated Organisations: | Department of Urology, Royal Melbourne Hospital, Melbourne, Australia Division of Cancer Surgery, Peter MacCallum Cancer Centre, University of Melbourne, Melbourne, Australia Department of Urology, Royal Melbourne Hospital, Melbourne, Australia |
| Appears in Collections: | Cancer Services Epworth Prostate Centre UroRenal, Vascular |
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