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Title: | Influence of fracture geometry on bone healing under locking plate fixations: A comparison between oblique and transverse tibial fractures. |
Epworth Authors: | Richardson, Martin |
Other Authors: | Miramini, Saeed Zhang, Lihai Mendis, Priyan Ebeling, Peter |
Keywords: | Bone Fracture Healing Cell Differentiation Computational Modelling Interfragmentary Movement Mechanical Testing Oblique Fracture Angle of Obliquity IFM Callus Strain Interstitial Fluid Flow Musculoskeletal Clinical Institute, Epworth HealthCare, Victoria, Australia |
Issue Date: | Jul-2016 |
Publisher: | Elsevier |
Citation: | Med Eng Phys. 2016 Jul 27. pii: S1350-4533(16)30155-2 |
Abstract: | Mechano-regulation plays a crucial role in bone healing and involves complex cellular events. In this study, we investigate the change of mechanical microenvironment of stem cells within early fracture callus as a result of the change of fracture obliquity, gap size and fixation configuration using mechanical testing in conjunction with computational modelling. The research outcomes show that angle of obliquity (θ) has significant effects on interfragmentary movement (IFM) which influences mechanical microenvironment of the callus cells. Axial IFM at near cortex of fracture decreases with θ, while shear IFM significantly increases with θ. While a large θ can increase shear IFM by four-fold compared to transverse fracture, it also result in the tension-stress effect at near cortex of fracture callus. In addition, mechanical stimuli for cell differentiation within the callus are found to be strongly negatively correlated to angle of obliquity and gap size. It is also shown that a relatively flexible fixation could enhance callus formation in presence of a large gap but could lead to excessive callus strain and interstitial fluid flow when a small transverse fracture gap is present. In conclusion, there appears to be an optimal fixation configuration for a given angle of obliquity and gap size. |
URI: | http://hdl.handle.net/11434/761 |
DOI: | 10.1016/j.medengphy.2016.07.007 |
PubMed URL: | http://www.ncbi.nlm.nih.gov/pubmed/27475782 |
ISSN: | 1350-4533 |
Journal Title: | Medical Engineering & Physics |
Type: | Journal Article |
Affiliated Organisations: | Department of Infrastructure Engineering, The University of Melbourne, Victoria 3010, Australia Department of Medicine, School of Clinical Sciences, Monash University, Monash Medical Centre, Victoria 3168, Australia |
Type of Clinical Study or Trial: | Cohort Study |
Appears in Collections: | Musculoskeletal |
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