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Title: Morphological approach to hair disorders.
Epworth Authors: Sinclair, Rodney
Other Authors: Jolley, Damien
Mallari, Rica
Magee, Jill
Tosti, A.
Piracinni, B. M.
Vincenzi, C.
Happle, R.
Ferrando, J.
Grimalt, R.
Therese, L.
Van Neste, D.
Zlotogorski, Abraham
Christiano, A. M.
Whiting, D.
Keywords: Alopecia
Hair Diseases
Hair Follicle
Molecular Biology
Reproducibility of Results
Scalp Dermatoses
Therapeutic Intervention
Department of Dermatology, Epworth Hospital, Richmond, Victoria, Australia
Issue Date: Jun-2003
Publisher: Elsevier
Citation: J Investig Dermatol Symp Proc. 2003 Jun;8(1):56-64.
Abstract: The Workshop on the morphological approach to hair disorders brought together a group of clinicians involved in hair biology research. Six speakers spoke on a range of topics that can be grouped broadly into a central theme. It summarizes the evolution of medical research. The section by Tosti and coworkers describes a patient with a new unique syndrome. The section by Ferrando and colleagues provides a framework in which patients with rare hair disorders can be classified. The section by Whiting tries to define the normal anatomy of the hair follicle and both horizontal and vertical sections. It is only when normal anatomy has been absolutely defined that pathological deviations can be recognized. The section by Sinclair and coworkers attempts to estimate the reliability of histological diagnosis so that its true value of pathology can be recognized. The section by Zlotogorski and coworkers shows how accurate clinical and histological definition of disease acts as the cornerstone for gene discovery techniques. Once a causative mutation is found and a gene product identified, then the biological consequences of the altered protein product can be studied and the impact of the abnormal molecular function on hair biology can be understood. It is hoped that improved understanding of hair disease will then lead to useful therapeutic interventions. The final section by Leroy and Van Neste highlights the difficulties of evaluating therapeutic interventions in hair loss disease and proposes a new technique.
DOI: 10.1046/j.1523-1747.2003.12172.x
PubMed URL:
ISSN: 1087-0024
Journal Title: Journal of Investigative Dermatology Symposium Proceedings
Type: Journal Article
Affiliated Organisations: Department of Dermatology, University of Melbourne, Victoria, Australia
Type of Clinical Study or Trial: Review
Appears in Collections:Dermatology
Head & Neck

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