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dc.contributor.authorde Steiger, Richard-
dc.contributor.otherRobinson, D. L.-
dc.contributor.otherKersh, M. E.-
dc.contributor.otherWalsh, N. C.-
dc.contributor.otherAckland, David-
dc.contributor.otherPandy, Marcus-
dc.identifier.citationJ Mech Behav Biomed Mater. 2016 Jan 23;61:96-109en_US
dc.description.abstractIsotropic hyperelastic models have been used to determine the material properties of normal human cartilage, but there remains an incomplete understanding of how these properties may be altered by osteoarthritis. The aims of this study were to (1) measure the material constants of normal and osteoarthritic human knee cartilage using isotropic hyperelastic models; (2) determine whether the material constants correlate with histological measures of structure and/or cartilage tissue damage; and (3) quantify the abilities of two common isotropic hyperelastic material models, the neo-Hookean and Yeoh models, to describe articular cartilage contact force, area, and pressure. Small osteochondral specimens of normal and osteoarthritic condition were retrieved from human cadaveric knees and from the knees of patients undergoing total knee arthroplasty and tested in unconfined compression at loading rates and large strains representative of weight-bearing activity. Articular surface contact area and lateral deformation were measured concurrently and specimen-specific finite element models then were used to determine the hyperelastic material constants. Structural parameters were measured using histological techniques while the severity of cartilage damage was quantified using the OARSI grading scale. The hyperelastic material constants correlated significantly with OARSI grade, indicating that the mechanical properties of cartilage for large strains change with tissue damage. The measurements of contact area described anisotropy of the tissue constituting the superficial zone. The Yeoh model described contact force and pressure more accurately than the neo-Hookean model, whereas both models under-predicted contact area and poorly described the anisotropy of cartilage within the superficial zone. These results identify the limits by which isotropic hyperelastic material models may be used to describe cartilage contact variables. This study provides novel data for the mechanical properties of normal and osteoarthritic human articular cartilage and enhances our ability to model this tissue using simple isotropic hyperelastic materials.en_US
dc.subjectIsotropic Hyperelastic Modelsen_US
dc.subjectLarge Deformationen_US
dc.subjectRadial Strainen_US
dc.subjectOsteoarthritic Knee Cartilageen_US
dc.subjectYeoh Modelen_US
dc.subjectOARSI Gradingen_US
dc.subjectDepartment of Surgery, Epworth Healthcare, Victoria, Australia.en_US
dc.titleMechanical properties of normal and osteoarthritic human articular cartilage.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleJournal of the Mechanical Behavior of Biomedical Materialsen_US
dc.description.affiliatesDept. of Mechanical Engineering, University of Melbourne, Parkville, Victoria 3010, Australia.en_US
dc.description.affiliatesDept. of Mechanical Science and Engineering, University of Illinois at Urbana-Champaign, IL 61801, USA.en_US
dc.description.affiliatesSt Vincent׳s Institute of Medical Research and Department of Medicine at St Vincent׳s Hospital, Melbourne, Victoria 3000, Australia.en_US
dc.description.affiliatesDept. of Surgery, University of Melbourne, Parkville, Victoria 3010, Australia.en_US
dc.type.studyortrialComparative Studyen_US
Appears in Collections:Musculoskeletal

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