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Title: Utility of RhoC and ZAG protein expression as biomarkers for prediction of PSA failure following radical prostatectomy for high grade prostate cancer
Epworth Authors: Peters, Justin
Costello, Anthony
Harewood, Laurence
Other Authors: Mills, John
Oliver, Alice
Frydenberg, Mark
Love, Christopher
Redgrave, Nicholas
Van Golen, Kenneth
Bailey, Michael
Pedersen, John
Keywords: Australian Prostate Cancer Research Centre at Epworth Hospital, Richmond
Carrier Proteins
Neoplasm Grading
Prostate Cancer
Rho GTP-Binding Proteins
Treatment Outcome
Tumor Markers
Predictive Value of Tests
Gleason Pattern
RhoC Protein
ZAG Protein
Issue Date: Oct-2012
Publisher: Lippincott Williams & Wilkins
Citation: Pathology. 2012 Oct;44(6):513-8
Abstract: Aims: To assess the prognostic utility of semi-quantiative expression of RhoC protein in whole prostates from patients who had radical prostatectomies for high grade prostate cancer (PCa). Methods: Subjects who had surgery >55 months previously with primary Gleason pattern 4 PCa were identified from practice records, archival tissues were retrieved for review and RhoC immunohistochemistry, and ZAG expression was also assessed as a control. Results: Eighty-nine subjects were included in the study; 57 had a rising prostate specific antigen (PSA) post-operatively ('cases') and 32 did not ('controls'). By univariate analysis, expression of both RhoC and ZAG proteins was greater in controls than cases, but this was significant only for ZAG. By multivariate analysis, Gleason variables (patterns and score), extraprostatic extension and decreased RhoC staining all contributed to predicting PSA failure (p < 0.05). ZAG expression was inversely correlated with Gleason pattern and hence was not independently predictive in our multivariate model. Conclusions: Increased RhoC expression predicted a good outcome after radical prostatectomy. ZAG staining also correlated with a favourable outcome but was not independently predictive due to its relationship with Gleason pattern.
DOI: 10.1097/PAT.0b013e3283581780
PubMed URL:
ISSN: 1465-3931
Journal Title: Pathology
Type: Journal Article
Affiliated Organisations: Department of Medicine, Central Clinical School, Monash University, Melbourne
Department of Surgery, Monash University, Clayton
Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne
Alfred Hospital, Melbourne, and Monash University Faculty of Medicine, Melbourne, Victoria, Australia
Department of Biological Sciences, University of Delaware, Newark, DE, USA
Type of Clinical Study or Trial: Retrospective studies
Appears in Collections:Cancer Services
Epworth Prostate Centre
UroRenal, Vascular

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