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Title: Factors associated with posttraumatic stress disorder following moderate to severe traumatic brain injury: a prospective study.
Epworth Authors: Ponsford, Jennie
Johnston, Lisa
Other Authors: Alway, Yvette
McKay, Adam
Gould, Kate
Keywords: Monash-Epworth Rehabilitation Research Centre, Richmond, Victoria, Australia.
Anxiety Disorders
Neuroses, Anxiety
Stress Disorders, Post-Traumatic
Posttraumatic Stress Disorders
Neuroses, Posttraumatic
Quality of Life
Recovery of Function
Disability Evaluation
Brain Injuries
Injuries, Brain
Trauma, Brain
Traumatic Brain Injury
Patient Outcome Assessment
Assessment, Patient Outcomes
Outcomes Assessments, Patient
Patient Admission
Issue Date: Jul-2015
Publisher: Wiley Online Library
Citation: Depression and Anxiety 2015 Jul 28
Abstract: BACKGROUND: This study prospectively examined the relationship between preinjury, injury-related, and postinjury factors and posttraumatic stress disorder (PTSD) following moderate to severe traumatic brain injury (TBI). METHOD: Two hundred and three participants were recruited during inpatient admission following moderate to severe TBI. Participants completed an initial assessment soon after injury and were reassessed at 3, 6, and 12 months, 2, 3, 4, and 5 years postinjury. The Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders-fourth edition was used to diagnose pre- and postinjury PTSD and other psychiatric disorders. The Glasgow Outcome Scale-Extended (GOSE) and the Quality of Life Inventory (QOLI) were used to evaluate functional and psychosocial outcome from 6 months postinjury. RESULTS: The frequency of PTSD ranged between 0.5 and 9.4% during the 5-year period, increasing throughout the first 12 months and declining thereafter. After controlling for other predictors, shorter posttraumatic amnesia duration (odds ratio = 0.96, 95% CI = 0.92-1.00), other concurrent psychiatric disorder (odds ratio = 14.22, 95% CI = 2.68-75.38), and lower GOSE (odds ratio = 0.38, 95% CI = 0.20-0.72) and QOLI scores (odds ratio = 0.97, 95% CI = 0.95-0.97) were associated with greater odds of having injury-related PTSD. DISCUSSION: The results of this study indicate that while shorter posttraumatic amnesia duration is associated with PTSD, greater TBI severity does not prevent PTSD from evolving. Patients with PTSD experienced high rates of psychiatric comorbidity and poorer functional and quality of life outcomes after TBI. CONCLUSION: There is a need to direct clinical attention to early identification and treatment of PTSD following TBI to improve outcomes.
DOI: 10.1022/da.22396
PubMed URL:
ISSN: 1520-6394
Journal Title: Depression and Anxiety
Type: Journal Article
Affiliated Organisations: School of Psychological Sciences, Monash University, Melbourne, Victoria, Australia
National Trauma Research Institute, Melbourne, Victoria, Australia
Type of Clinical Study or Trial: Prospective Cohort Study
Appears in Collections:Mental Health

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