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Title: Curated microRNAs in urine and blood fail to validate as predictive biomarkers for high-risk prostate cancer.
Epworth Authors: Sapre, Nikhil
Hong, Matthew
Lewis, Heather
Costello, Anthony
Corcoran, Niall
Hovens, Christopher
Other Authors: Macintyre, Geoff
Kowalczyk, Adam
Keywords: Prostate Cancer
Prostatic Neoplasms
Biological Markers
Genetic Testing
Australian Prostate Cancer Research Epworth, Richmond, Victoria, Australia.
Issue Date: Apr-2014
Citation: PLoS One. 2014 Apr 4;9(4):e91729. eCollection 2014.
Abstract: The purpose of this study was to determine if microRNA profiling of urine and plasma at radical prostatectomy can distinguish potentially lethal from indolent prostate cancer. A panel of microRNAs was profiled in the plasma of 70 patients and the urine of 33 patients collected prior to radical prostatectomy. Expression of microRNAs was correlated to the clinical endpoints at a follow-up time of 3.9 years to identify microRNAs that may predict clinical response after radical prostatectomy.
DOI: 10.1371/journal.pone.0091729
PubMed URL:
ISSN: 1932-6203
Journal Title: PLoS One (Public Library of Science).
Type: Journal Article
Affiliated Organisations: Division of Urology, Department of Surgery, Royal Melbourne Hospital and the University of Melbourne, Parkville, Victoria, Australia
NICTA Victoria Research Laboratory, Department of Electronic and Electrical Engineering, The University of Melbourne, Parkville, Victoria, Australia
Department of Computing and Information Systems, The University of Melbourne, Parkville, Victoria, Australia
Type of Clinical Study or Trial: Validation Study
Appears in Collections:Cancer Services
Epworth Prostate Centre
UroRenal, Vascular

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