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Title: Advances in the imaging of the prostate in the setting of elevated PSA levels.
Epworth Authors: Murphy, Declan
Lawrentschuk, Nathan
Other Authors: Hicks, Rodney
Parameswaran, Bimal
Hofman, Michael
Williams, Scott
Keywords: Prostate Cancer
Advanced Imaging Techniques
Cancer Treatment
Prostate Specific Membrane Antigen Receptor
Metastatic Disease
Multi-parametric Magnetic Resonance Imaging
Multi-parametric MRI
Positron Emission Tomography
PET Scan
Computed Tomography
CT Scan
Prostate-Specific Antigen
Molecular Imaging
Therapeutic Response
Cancer Services Clinical Institute, Epworth HealthCare, Victoria, Australia
​UroRenal & Vascular Clinical Institute, Epworth HealthCare, Victoria, Australia
Australian Prostate Cancer Research Centre, Epworth Healthcare, Victoria, Australia
Issue Date: Nov-2015
Publisher: Cancer Council Australia
Citation: Cancer Forum, Vol. 39, No. 3, Nov 2015: 173-177.
Abstract: Mirroring exciting advances in the treatment of prostate cancer, advanced imaging techniques are providing improved detection and staging of this disease. Whereas treatment decisions were previously often made on the basis of probability, more sensitive and specific localisation of disease sites will allow choices that are better tailored to an individual patient’s disease. Multi-parametric MRI and PET/CT, particularly using ligands of the prostate specific membrane antigen receptor provide improved assessment of the prostate and, in the post-treatment setting, prostate bed and of nodal and distant metastatic disease both prior to definitive treatment of high-risk cases and at PSA failure following definitive treatment of the prostate. PET/CT may also help to select patients for targeted therapies based on prostate specific membrane antigen receptor expression, including emerging radionuclide therapy approaches. As well as localising disease sites, molecular imaging also provides opportunities to better characterise and predict biological behaviour and therapeutic response than current imaging techniques. However, despite great enthusiasm and rapid adoption of these techniques in clinical practice, there is a pressing need to better define their role in selecting, planning and monitoring treatment through further, well designed and validated studies.
ISSN: 0311-306X
Journal Title: Cancer Forum
Type: Journal Article
Affiliated Organisations: Division of Radiation Oncology and Cancer Imaging, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
The Sir Peter MacCallum Department of Oncology,Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Cancer Surgery Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
The University of Melbourne, Victoria, Australia.
Type of Clinical Study or Trial: Review
Appears in Collections:Cancer Services
Epworth Prostate Centre
UroRenal, Vascular

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