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Title: The arrector pili muscle, the bridge between the follicular stem cell niche and the interfollicular epidermis.
Epworth Authors: Sinclair, Rodney
Torkamani, Niloufar
Rufaut, Nicholas
Jones, Leslie
Keywords: Arrector Pili Muscle
Stem Cell
F-actin Probe
Androgenic Alopecia
Follicular Integrity
Dermatology Research Centre, Epworth HealthCare
Chair of Dermatology, Epworth HealthCare
Head & Neck Clinical Institute, Epworth HealthCare, Victoria, Australia
Issue Date: Jul-2016
Publisher: Springer
Citation: Anat Sci Int. 2017 Jan;92(1):151-158. Epub 2016 Jul 29.
Abstract: Proximally, the arrector pili muscle (APM) attaches to the follicular stem cell niche in the bulge, but its distal properties are comparatively unclear. In this work, a novel method employing an F-actin probe, phalloidin, was employed to visualize the APM anatomy. Phalloidin staining of the APM was validated by comparison with conventional antibodies/stains and by generating three-dimensional reconstructions. The proximal attachment of the APM to the bulge in 8 patients with androgenic alopecia was studied using Masson's trichrome stain. Phalloidin visualized extensive branching of the APM. The distal end of the human APM exhibits a unique "C"-shaped structure connecting to the dermal-epidermal junction. The proximal APM attachment was observed to be lost or extremely miniaturized in androgenic alopecia. The unique shape, location, and attachment sites of the APM suggest a significant role for this muscle in maintaining follicular integrity. Proximally, the APM encircles the follicular unit and only attaches to the primary hair follicle in the bulge; this attachment is lost in irreversible hair loss. The APM exhibits an arborized morphology as it ascends toward the epidermis, and anchors to the basement membrane.
DOI: 10.1007/s12565-016-0359-5
PubMed URL:
ISSN: 1447-6959
Journal Title: Anatomical Science International
Type: Journal Article
Affiliated Organisations: Department of Dermatology, School of Medicine and Dentistry, University of Melbourne, Australia.
Type of Clinical Study or Trial: Comparative Study
Appears in Collections:Head & Neck

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