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Title: The relationship between age, injury severity, and MRI findings after traumatic brain injury.
Epworth Authors: Schonberger, Michael
Ponsford, Jennie
O'Sullivan, Richard
Other Authors: Reutens, D.
Beare, R.
Keywords: Traumatic Brain Injury
Glasgow Coma Scale
Post Traumatic Amnesia
Brain Lesion Volumes
White Matter
Grey Matter
Brain Damage
Monash-Epworth Rehabilitation Research Centre, Epworth HealthCare, Australia
Rehabilitation, Mental Health and Chronic Pain Clinical Institute, Epworth HealthCare, Victoria, Australia
Issue Date: Dec-2009
Publisher: Mary Ann Liebert
Citation: J Neurotrauma. 2009 Dec;26(12):2157-67
Abstract: Age and injury severity are among the most significant predictors of outcome after traumatic brain injury (TBI). However, only a few studies have investigated the association between, age, injury severity, and the extent of brain damage in TBI. The purpose of this study was to investigate the association between age, measures of injury severity, and brain lesion volumes, as well as viable brain volumes, following TBI. Ninety-eight individuals with mild to very severe TBI (75.5% male, mean age at injury 34.5 years) underwent a structural MRI scan, performed with a 1.5-Tesla machine, on average 2.3 years post-injury. Lesion volumes were highly skewed in their distribution and were dichotomized for statistical purposes. Measures of injury severity were Glasgow Coma Scale score (GCS) and duration of post-traumatic amnesia (PTA). Logistic regression analyses predicting lesion volumes, controlling for participants' gender, cause of injury, time from injury to MRI scan, and total brain volume, revealed that both older age and longer PTA were associated with larger lesion volumes in both grey and white matter in almost all brain regions. Older age was also associated with smaller viable grey matter volumes in most neo-cortical brain regions, while longer PTA was associated with smaller viable white matter volumes in most brain regions. The results suggest that older age worsens the impact of TBI on the brain. They also indicate the validity of duration of PTA as a measure of injury severity that is not just related to one particular injury location.
DOI: 10.1089/neu.2009.0939
PubMed URL:
ISSN: 0897-7151
Journal Title: Journal of Neurotrauma
Type: Journal Article
Affiliated Organisations: School of Psychology, Psychiatry, and Psychological Medicine, Monash University, Melbourne, Australia
Type of Clinical Study or Trial: Predictive Value of Tests
Appears in Collections:Diagnostic Services

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