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Title: The normal tissue effects of microbeam radiotherapy: what do we know, and what do we need to know to plan a human clinical trial?
Epworth Authors: Smyth, Lloyd
Other Authors: Senthi, Sashendra
Crosbie, Jeffrey
Rogers, Peter
Keywords: Radiotherapy
Microbream Radiotherapy
Conventional Radiotherapy
Dose-Response Curve
Pre-Clinical Cancer Therapy
Animal Studies
Tissue Toxicity Data
Epworth Radiation Oncology, Australia
Issue Date: Mar-2016
Publisher: Taylor & Francis
Citation: Int J Radiat Biol. 2016 Mar 16:1-10
Abstract: Purpose: Microbeam Radiotherapy (MRT) is a promising pre-clinical cancer therapy which represents a radical departure from the radiobiological principles of conventional radiotherapy (CRT). In order to translate MRT to human clinical trials, robust normal tissue toxicity data are required. This review summarizes the normal tissue effects reported by pre-clinical MRT animal studies and compares these data to clinical recommendations in CRT. Conclusion: Few pre-clinical studies are specifically designed to evaluate the dose-response of normal tissue to MRT. However, it remains clear that a range of normal tissues can tolerate peak MRT doses at least an order of magnitude higher than CRT. Furthermore, the dose deposited in the valley regions, predominantly determined by microbeam spacing, has a greater influence on the normal tissue response to MRT compared to the peak regions. The development of a new normal tissue complication probability model for MRT, in conjunction with a treatment planning system, will be pivotal in the collection of robust normal tissue toxicity data and the translation of MRT to clinical use.
DOI: 10.3109/09553002.2016.1154217
PubMed URL:
ISSN: 0955-3002
Journal Title: International Journal of Radiation Biology
Type: Journal Article
Affiliated Organisations: University of Melbourne, Department of Obstetrics and Gynaecology , Royal Women's Hospital, Parkville , Victoria , Australia
William Buckland Radiotherapy Centre , Alfred Hospital , Melbourne, Victoria , Australia
School of Applied Sciences, RMIT University , Melbourne , Victoria , Australia
Type of Clinical Study or Trial: Review
Appears in Collections:Cancer Services
Radiation Oncology

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