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Title: Androgenetic alopecia: new insights into the pathogenesis and mechanism of hair loss.
Epworth Authors: Sinclair, Rodney
Other Authors: Torkamani, Niloufar
Jones, Leslie
Keywords: Androgenetic Alopecia
Hair Loss
Stem Cell Biology
Organ Regeneration
Chair of Dermatology, Epworth HealthCare, Victoria, Australia
Head & Neck Clinical Institute, Epworth HealthCare, Victoria, Australia
Issue Date: Aug-2015
Citation: F1000Res. 2015 Aug 19;4(F1000 Faculty Rev):585.
Abstract: The hair follicle is a complete mini-organ that lends itself as a model for investigation of a variety of complex biological phenomena, including stem cell biology, organ regeneration and cloning. The arrector pili muscle inserts into the hair follicle at the level of the bulge- the epithelial stem cell niche. The arrector pili muscle has been previously thought to be merely a bystander and not to have an active role in hair disease. Computer generated 3D reconstructions of the arrector pili muscle have helped explain why women with androgenetic alopecia (AGA) experience diffuse hair loss rather than the patterned baldness seen in men. Loss of attachment between the bulge stem cell population and the arrector pili muscle also explains why miniaturization is irreversible in AGA but not alopecia areata. A new model for the progression of AGA is presented.
DOI: 10.12688/f1000research.6401.1
PubMed URL:
Journal Title: F1000 Research
Type: Journal Article
Affiliated Organisations: Department of Medicine, University of Melbourne, Victoria, Australia.
Type of Clinical Study or Trial: Review
Appears in Collections:Dermatology
Head & Neck

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