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Title: The association between apolipoprotein E and traumatic brain injury severity and functional outcome.
Epworth Authors: Ponsford, Jennie
Olver, John
Schonberger, Michael
Other Authors: McClaren, A.
Burke, Richard
Rudzki, Dion
Keywords: Traumatic Brain Injury
Brain Injuries
Apolipopritein E
Injury Severity
Severity of Illness
Recovery of Function
Patient Outcome
Glasgow Coma Scale
Glasgow Outcome Scale-Extended
Monash-Epworth Rehabilitation Research Centre, Epworth Hospital, Melbourne, Victoria, Australia.
Rehabilitation, Mental Health and Chronic Pain Clinical Institute, Epworth HealthCare, Victoria, Australia
Issue Date: May-2011
Publisher: Mary Ann Liebert Inc
Citation: J Neurotrauma. 2011 Sep;28(9):1683-92.
Abstract: Traumatic brain injury (TBI) can result in significant disability, but outcome is variable. The impact of known predictors accounts for a limited proportion of the variance in outcomes. Apolipoprotein E (ApoE) genotype has been investigated as an additional source of variability in injury severity and outcome, with mixed findings reflecting variable methodology and generally limited sample sizes. This study aimed to examine whether possession of the ApoE ɛ4 allele was associated with greater acute injury severity and poorer long-term outcome in patients referred for rehabilitation following TBI. ApoE genotype was determined for 648 patients with TBI, who were prospectively followed up a mean of 1.9 years post-injury. Hypotheses that ɛ4 carriers would have lower Glasgow Coma Scale (GCS) scores and longer post-traumatic amnesia (PTA) duration were not supported. Prediction of worse Glasgow Outcome Scale-Extended (GOSE) scores for ɛ4 carriers was supported with greater susceptibility seen in females. These results indicate the ApoE ɛ4 allele may be associated with poorer long-term outcome, but not acute injury severity. Possible mechanisms include differential effects of the ɛ4 allele on inflammatory and cellular repair processes, and/or amyloid deposition.
DOI: 10.1089/neu.2010.1623
PubMed URL:
ISSN: 0897-7151
Journal Title: Journal of Neurotrauma
Type: Journal Article
Affiliated Organisations: School of Psychology and Psychiatry, Monash University, Melbourne, Victoria, Australia.
Type of Clinical Study or Trial: Cohort Study
Appears in Collections:Neurosciences

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