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Title: Role of genetics and sex steroid hormones in male androgenetic alopecia and female pattern hair loss: an update of what we now know.
Epworth Authors: Sinclair, Rodney
Yip, Leona
Rufaut, Nick
Keywords: Alopecia
Female Pattern Hair Loss
Genetic Testing
Multifactorial Inheritance
Male Androgenetic Alopecia
Genetic Testing
Chair of Dermatology, Epworth HealthCare, Victoria, Australia
Head & Neck Clinical Institute, Epworth HealthCare, Victoria, Australia
Issue Date: May-2011
Publisher: Wiley
Citation: Australas J Dermatol. 2011 May;52(2):81-8.
Abstract: The role of genetic predisposition and the influence of sex steroid hormones are indisputable to the pathogenesis of male androgenetic alopecia (MAGA). The role of sex steroid hormones in female pattern hair loss (FPHL) is less known. A good knowledge of the pathophysiology underlying MAGA and FPHL empowers the clinician to confidently counsel patients and make informed therapeutic decisions. Vigorous research in recent years has provided greater insight into the role of genetics and sex steroids in physiological hair growth and cycling, as well as in hair follicle miniaturization, the histological hallmark of MAGA and FPHL. In the present review article directed towards clinicians, we discuss the current understanding of the role of androgens and oestrogens, as well as genetic associations with MAGA and FPHL. We also briefly discuss the interpretation of direct-to-consumer genetic testing for baldness to help clinicians understand the limitations of such tests.
DOI: 10.1111/j.1440-0960.2011.00745.x
PubMed URL:
ISSN: 1440-0960
Journal Title: Australasian Journal of Dermatology
Type: Journal Article
Affiliated Organisations: Department of Dermatology, St Vincent's Hospital, Melbourne, Victoria, Australia
Type of Clinical Study or Trial: Review
Appears in Collections:Dermatology
Head & Neck

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