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Title: Prospective assessment of the false positive rate of the Australian Snake Venom Detection Kit in healthy human samples.
Epworth Authors: Nimorakiotakis, V (Bill)
Other Authors: Winkel, K
Keywords: Emergency Department, Epworth Hospital, 89 Bridge Road, Richmond, Victoria, Australia.
Snake Venoms
Snake Bites
Confidence Intervals
Assays, Biological
Biological Assay
Snake Venom Detection Kit
Issue Date: Dec-2015
Publisher: Elsevier
Citation: Toxicon. 2015 Dec 12. pii: S0041-0101(15)30145-8.
Abstract: The Snake Venom Detection Kit (SVDK; bioCSL Pty Ltd, Australia) distinguishes venom from the five most medically significant snake immunotypes found in Australia. This study assesses the rate of false positives that, by definition, refers to a positive assay finding in a sample from someone who has not been bitten by a venomous snake. Control unbroken skin swabs, simulated bite swabs and urine specimens were collected from 61 healthy adult volunteers [33 males and 28 females] for assessment. In all controls, simulated bite site and urine samples [a total of 183 tests], the positive control well reacted strongly within one minute and no test wells reacted during the ten minute incubation period. However, in two urine tests, the negative control well gave a positive reaction (indicating an uninterpretable test). A 95% confidence interval for the false positive rate, on a per-patient rate, derived from the findings of this study, would extend from 0% to 6% and, on a per-test basis, it would be 0 to 2%. It appears to be a very low incidence (0-6%) of intrinsic true false positives for the SVDK. The clinical impresssion of a high SVDK false positive rate may be mostly related to operator error.
DOI: 10.1016/j.toxicon.2015.12.002
PubMed URL:
ISSN: 0041-0101
Journal Title: Toxicon
Type: Journal Article
Affiliated Organisations: Sunshine Hospital, St Albans, Victoria, Australia.
Retrieval Services Queensland, Robina, Queensland, Australia.
Australian Venom Research Unit, Department of Pharmacology and Therapeutics, University of Melbourne, Victoria, Australia.
Type of Clinical Study or Trial: Prospective Study
Appears in Collections:Emergency Care

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