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Title: Breast implant associated anaplastic large cell lymphoma: Evidence-based consensus conference statement from the American Association of Plastic Surgeons.
Epworth Authors: Prince, H Miles
Other Authors: Clemens, Mark W
Myckatyn, Terence
Di Napoli, Arianna
Feldman, Andrew L
Jaffe, Elaine S
Haymaker, Cara L
Horwitz, Steven M
Hunt, Kelly K
Kadin, Marshall E
McCarthy, Colleen M
Roberto N Miranda, Roberto N
Santanelli di Pompeo, Fabio
Holmes, Sari D
Phillips, Linda G
Keywords: Cancer Services Clinical Institute, Epworth HealthCare, Victoria, Australia
Issue Date: Feb-2024
Publisher: Wolters Kluwer Health (United States)
Citation: Plast Reconstr Surg . 2024 Feb 27.
Abstract: Background: In the absence of high-quality evidence, there is a need to provide guidelines and multidisciplinary consensus recommendations on Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL). The purpose of this expert consensus conference was to evaluate the existing evidence regarding the diagnosis, and management of BIA-ALCL caused by textured implants. The aim is to provide evidence-based recommendations regarding the management and prevention of BIA-ALCL. Methods: A comprehensive search was conducted in the MEDLINE, Cochrane Library, and Embase databases, supplemented by manual searches of relevant English language articles and "related articles" sections. Studies focusing on breast surgery and lymphoma associated with breast implants were included for analysis. Meta-analyses were performed and reviewed by experts selected by the American Association of Plastic Surgeons by a Delphi consensus method. Results: 840 articles between January 2011 and January 2023 were initially identified and screened. Full-text of 188 articles were assessed. An additional 43 articles were excluded for focus, and 145 articles were included in the synthesis of results, with 105 of them being case reports or case series. The analysis encompassed a comprehensive examination of the selected articles to determine the incidence, risk factors, clinical presentation, diagnostic approaches, and treatment modalities related to BIA-ALCL. Conclusions: Plastic surgeons should be aware of the elevated risks by surface type, implement appropriate patient surveillance, and follow the recommendations outlined in this statement to ensure patient safety and optimize outcomes. Ongoing research on pathogenesis, genetic drivers, and preventative and prophylactic measures is crucial for improving patient care.
DOI: DOI: 10.1097/PRS.0000000000011370
PubMed URL:
ISSN: 0032-1052
Journal Title: Plastic & Reconstructive Surgery
Type: Journal Article
Affiliated Organisations: MD Anderson Cancer Center, University of Texas, Houston, TX, USA
Washington University School of Medicine, St. Louis, MO, USA
NESMOS Department, Faculty of Medicine and Psychology, Sapienza University of Rome, Sant'Andrea Hospital, Rome, Italy
Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, MN
Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
Memorial Sloan Kettering Cancer Center, New York NY, USA
Pathology and Laboratory Medicine, Brown University Alpert School of Medicine, Providence, RI, USA
Johns Hopkins University School of Medicine, Baltimore, MD, USA
University of Texas Medical Branch (UTMB), Galveston, TX, USA
Type of Clinical Study or Trial: Meta-Analysis
Appears in Collections:Cancer Services

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