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Title: A molecular staging model for accurately dating the endometrial biopsy.
Epworth Authors: Holdsworth-Carson, Sarah
Other Authors: Teh, Wan
Chung, Jessica
Donoghue, Jacqueline
Healey, Martin
Rees, H
Bittinger, Sophie
Obers, Vanessa
Sloggett, Clare
Kendarsari, Raden
Fung, Jenny
Mortlock, Sally
Montgomery, Grant
Girling, Jane
Rogers, Peter
Keywords: Biopsy
Endometrial Gene Expression
Endometrial Cycle
Molecular Staging Model
Recurrent Implantation Failure
Julia Argyrou Endometriosis Centre, Epworth HealthCare, Victoria, Australia
Women's and Children's Clinical Institute, Epworth HealthCare, Victoria, Australia
Issue Date: Oct-2023
Publisher: Nature Publishing Group
Citation: Nat Commun . 2023 Oct 6;14(1):6222
Abstract: Natural variability in menstrual cycle length, coupled with rapid changes in endometrial gene expression, makes it difficult to accurately define and compare different stages of the endometrial cycle. Here we develop and validate a method for precisely determining endometrial cycle stage based on global gene expression. Our 'molecular staging model' reveals significant and remarkably synchronised daily changes in expression for over 3400 endometrial genes throughout the cycle, with the most dramatic changes occurring during the secretory phase. Our study significantly extends existing data on the endometrial transcriptome, and for the first time enables identification of differentially expressed endometrial genes with increasing age and different ethnicities. It also allows reinterpretation of all endometrial RNA-seq and array data that has been published to date. Our molecular staging model will significantly advance understanding of endometrial-related disorders that affect nearly all women at some stage of their lives, such as heavy menstrual bleeding, endometriosis, adenomyosis, and recurrent implantation failure.
DOI: 10.1038/s41467-023-41979-z
PubMed URL:
ISSN: 2041-1723
Journal Title: Nature Communications
Type: Journal Article
Affiliated Organisations: University of Melbourne Department of Obstetrics and Gynaecology, Victoria, Australia
Royal Women's Hospital, Victoria, Australia
Melbourne Bioinformatics, University of Melbourne, Victoria, Australia
Royal Children's Hospital, Victoria, Australia
Microbiological Diagnostic Unit Public Health Laboratory, Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute, Victoria, Australia.
Institute for Molecular Bioscience, University of Queensland, Queensland, Australia
School of Biomedical Sciences, University of Queensland, Queensland, Australia
Department of Anatomy, School of Biomedical Sciences, University of Otago, New Zealand.
Type of Clinical Study or Trial: Validation Study
Appears in Collections:Women's and Children's

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