Malignant transformation of Intraductal Papillary Mucinous Neoplasm (IPMN): a multi-centre retrospective analysis from the IPMN registry.

Abstract

Introduction: Pancreatic ductal adenocarcinoma (PDAC) is predicted to become the second most lethal cancer in Australia by 2030 and early detection of the cancer is crucial for timely surgical intervention [1]. Intraductal Papillary Mucinous Neoplasms (IPMN) are the most common radiological detectable precursor lesion to PDAC. Data from international cohorts demonstrates different malignant potentials for main duct and branch duct IPMNs. Multiple surveillance guidelines for IPMN have been proposed but there are still gaps in our knowledge of the natural history of these neoplasms. Conclusions: Classification of IPMN based on Fukuoka consensus correlates with the incidence of PDAC. The majority of those with or developing high-risk stigmata are not undergoing surgery. To further investigate the validity of the Fukuoka Consensus on the surveillance and treatment of IPMN, a prospective arm with a larger sample size, a more extended follow-up period and data on the clinical management of these patients is underway.