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Title: Plasma mass spectrometry-based proteomic biomarker discovery for endometriosis.
Epworth Authors: Holdsworth-Carson, Sarah
Other Authors: Rao, Sushma
Boughton, Berin
Snel, Marten
Pukala, Tara
Griffiths, Meaghan
Rogers, Peter
Girling, Jane
Keywords: Endometriosis
Mass Spectrometry
Proteomic Biomarker
Plasma Proteins
. Julia Argyrou Endometriosis Centre, Epworth HealthCare, Victoria, Australia
Issue Date: Oct-2023
Conference Name: Epworth HealthCare Research Month 2023
Conference Location: Epworth Research Institute, Victoria, Australia
Abstract: Background and Aim: Endometriosis diagnosis requires surgical visualisation of lesions and histopathology. To date, no non-invasive diagnostic test has been validated. Discovery research using sensitive high-throughput mass spectrometry (MS) has the potential to improve identification of clinically-relevant plasma proteins.The aim of this study was to undertake MS-based proteomic biomarker discovery using minimally-invasive plasma specimens from patients with and without endometriosis.Conclusions: High-throughput MS-based proteomic biomarker discovery successfully identified 470 proteins in an endometriosis cohort. Case-control analysis revealed significantly different protein expression profiles in association with endometriosis. Further validation in an independent sample set is underway. Biomarker discovery using plasma proteomics offers a minimally invasive approach to endometriosis diagnosis.
Type: Conference Poster
Affiliated Organisations: South Australian Health and Medical Research Institute, Adelaide, SA, Australia
Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia
Australian National Phenome Centre, Harry Perkins Institute of Medical Research, Murdoch, WA, Australia
School of Physical Sciences, University of Adelaide, Adelaide, SA, Australia
Department of Obstetrics and Gynaecology, University of Melbourne and Gynaecology Research Centre, Royal Women’s Hospital, Parkville, VIC, Australia
Department of Anatomy, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand
Type of Clinical Study or Trial: Case Control Studies
Appears in Collections:Research Month

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