Please use this identifier to cite or link to this item: http://hdl.handle.net/11434/2241
Title: Extracellular vesicles as biomarkers of endometriosis.
Epworth Authors: Vollenhoven, Beverley
Other Authors: James, Chloe
Farley, Johanna
Borash, Natasha
Tresso, Anna
Thota, Niharika
Shima, Bayat
Shah, Anup
Steele, Joel
Schittenhelm, Ralf B
Gurung, Shanti
Tapmeier, Thomas
Keywords: Endometriosis
Biomarkers
Extracellular Vesicles
Lesions
Blood Samples
Diagnosis
Women’s and Children’s Clinical Institute
Issue Date: Oct-2023
Conference Name: Epworth HealthCare Research Month 2023
Conference Location: Epworth Research Institute, Victoria, Australia
Abstract: We propose an origin of endometriotic lesions akin to the ‘seed and soil’ hypothesis in cancer, with extracellular vesicles (EVs) interacting with the intraperitoneal environment and the prospective lesion site, preparing the ground for attachment and growth of endometrium ectopically. EVs contain specific cargo from the cell of origin and would be good biomarkers of endometriosis, if found in the blood. We have shown that EVs can be directly isolated from PF and are now investigating blood samples in parallel to PF samples to see if we can trace the same EVs in both sample types. Conclusion: Extracellular vesicles are present in the peritoneal fluid and can be isolated directly. Women with endometriosis show endometriosis-specific vesicles in their PF. Whether the same vesicles can be traced in blood samples remains to be confirmed. Additional sample collection sites (Epworth) will speed up the discovery and validation work.
URI: http://hdl.handle.net/11434/2241
Type: Conference Poster
Affiliated Organisations: Monash University, Department of Obstetrics & Gynaecology, Clayton, Melbourne, Australia
The Ritchie Centre, Hudson Institute of Medical Research, Clayton, Melbourne, Australia
University of Trento, Trento, Trentino, Italy
Monash University, Monash Proteomics and Metabolomics Facility, Biomedicine Discovery Institute, Clayton, Melbourne, Australia
Women’s and Newborn Program, Monash Health
Type of Clinical Study or Trial: Observational Study
Appears in Collections:Research Month

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