Palmitoylethanolamide and polydatin effect on pain and dysmenorrhea in women scheduled for laparoscopic treatment of possible endometriosis: a double blind randomised controlled trial.

Abstract

Endometriosis effects at least 10% of reproductive age females worldwide; Effective medical therapies for the treatment of endometriosis related pelvic pain are limited and are often associated with side-effects. Palmitoylethanolamide (PEA) is a food supplement that has been shown to have anti-inflammatory action. Polydatin (PLD) is also a food supplement that has antioxidant and pain inhibiting activities. There have been some small studies performed to assess if the combination of PEA/PLD is helpful for persistent pain associated with endometriosis. The results suggest it might have benefit, but further studies are required.