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Title: Investigating uterine natural killer cells through next generation sequencing - A pilot gene expression study.
Epworth Authors: Teh, Wan
Other Authors: Rogers, Peter
Keywords: Uterine Natural Killer Cells
Next Generation Sequencing
Molecular Study
Molecular Markers
Human Reproduction
Protein Coding Genes
Immune Related Functions
Women’s and Children’s Clinical Institute, Epworth HealthCare, Melbourne, Australia
Issue Date: Oct-2022
Conference Name: Epworth HealthCare Research Month 2022
Conference Location: Epworth Research Institute, Victoria, Australia
Abstract: Uterine natural killer (uNK) cells form the major leucocyte population in the stroma in the late secretory phase endometrium. Their actual function is unknown with available data suggesting potential role in angiogenesis regulation, decidualization and placentation. Next generation sequencing (NGS) can be used to accurately define day of menstrual cycle through endometrial gene expression. Genes uniquely expressed by uNK are currently unknown. However, previous studies of first trimester decidua and blood have identified genes that are uniquely expressed by these NK cells (1-3). Aim for this study: To identify potential molecular markers of uNK cells.
Type: Conference Poster
Affiliated Organisations: Reproductive Services, Royal Women’s Hospital, Parkville 3052;
Melbourne IVF, East Melbourne 3002
Department of Obstetrics and Gynaecology, University of Melbourne, Royal Women’s Hospital, Parkville 3052, Victoria, Australia
Type of Clinical Study or Trial: Descriptive Study
Appears in Collections:Research Month

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