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Title: | Epigenetic Modifications in Lymphoma and Their Role in the Classification of Lymphomas |
Epworth Authors: | Prince, Henry Miles Yannakou, Costas |
Other Authors: | Harrop, Sean Van Der Weyden, Carrie |
Keywords: | B-Cell Lymphoma Follicular Lymphoma Diffuse Large B-Cell Lymphoma Mantle Cell Lymphoma Chronic Lymphocytic Leukaemia/Small Lymphocytic Leukaemia Marginal Zone Lymphoma Classical Hodgkin’s Lymphoma Peripheral T-Cell Lymphoma—TFH Phenotype Angioimmunoblastic Lymphoma Mycosis Fungoides and Sezary Syndrome Lymphomagenesis Methylation Histone modification |
Issue Date: | 21-Feb-2022 |
Publisher: | MDPI |
Citation: | Hemato 2022, 3(1), 174-187 |
Abstract: | The characterisation of the lymphoma epigenome has provided insight into mechanisms involved in lymphomagenesis. Multiple lymphoma subtypes demonstrate recurrent mutations in key epigenetic regulators that have been utilised to define clinicogenetic groups that can predict clinical behaviour in these heterogenous entities. The high frequency of mutations in epigenetic regulators provides rationale to incorporate these in the classification of some subtypes of lymphoma. In addition, their recurrent nature provides a rationale to target such mutations, or the relevant pathway, for treatment. In this review, we summarised the available literature on epigenetic dysregulation in lymphoma and how it has been utilised in diagnosis and classification. |
URI: | http://hdl.handle.net/11434/2125 |
DOI: | 10.3390/hemato3010015 |
Journal Title: | Hemato |
Type: | Journal Article |
Affiliated Organisations: | Peter MacCallum Cancer Center, Melbourne, VIC 3000, Australia Epworth HealthCare, East Melbourne, VIC 3002, Australia Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC 3052, Australia |
Appears in Collections: | MOCI |
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