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Title: Epigenetic Modifications in Lymphoma and Their Role in the Classification of Lymphomas
Epworth Authors: Prince, Henry Miles
Yannakou, Costas
Other Authors: Harrop, Sean
Van Der Weyden, Carrie
Keywords: B-Cell Lymphoma
Follicular Lymphoma
Diffuse Large B-Cell Lymphoma
Mantle Cell Lymphoma
Chronic Lymphocytic Leukaemia/Small Lymphocytic Leukaemia
Marginal Zone Lymphoma
Classical Hodgkin’s Lymphoma
Peripheral T-Cell Lymphoma—TFH Phenotype
Angioimmunoblastic Lymphoma
Mycosis Fungoides and Sezary Syndrome
Histone modification
Issue Date: 21-Feb-2022
Publisher: MDPI
Citation: Hemato 2022, 3(1), 174-187
Abstract: The characterisation of the lymphoma epigenome has provided insight into mechanisms involved in lymphomagenesis. Multiple lymphoma subtypes demonstrate recurrent mutations in key epigenetic regulators that have been utilised to define clinicogenetic groups that can predict clinical behaviour in these heterogenous entities. The high frequency of mutations in epigenetic regulators provides rationale to incorporate these in the classification of some subtypes of lymphoma. In addition, their recurrent nature provides a rationale to target such mutations, or the relevant pathway, for treatment. In this review, we summarised the available literature on epigenetic dysregulation in lymphoma and how it has been utilised in diagnosis and classification.
DOI: 10.3390/hemato3010015
Journal Title: Hemato
Type: Journal Article
Affiliated Organisations: Peter MacCallum Cancer Center, Melbourne, VIC 3000, Australia
Epworth HealthCare, East Melbourne, VIC 3002, Australia
Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC 3052, Australia
Appears in Collections:MOCI

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