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Title: Does switching between high frequency rTMS and theta burst stimulation improve depression outcomes?
Epworth Authors: Chen, Leo
Miljevic, Aleksandra
Hoy, Kate
Fitzgerald, Paul
Other Authors: Thomas, Elizabeth
Kaewpijit, Pakin
Hahn, Lisa
Lavale, Alexandra
Galletly, Cherrie
Keywords: Letter
Theta Burst Stimulation
Repetitive Transcranial Magnetic Stimulation
Resting Motor Threshold
Epworth Centre for Innovation in Mental Health, Epworth HealthCare and Department of Psychiatry, Monash University, Victoria, Australia.
Rehabilitation, Mental Health and Chronic Pain Clinical Institute
Issue Date: Jun-2022
Publisher: Elsevier
Citation: Brain Stimul . 2022 Jun 15;15(4):889-891
Abstract: To the editor, We read with interest recent articles in Brain Stimulation, reporting on the antidepressant effects of theta burst stimulation (TBS) applied in accelerated schedules [1,2] and the efficacy comparison between unilateral and bilateral repetitive transcranial magnetic stimulation (rTMS) approaches [3]. We recently reported a multisite randomized controlled trial comparing the antidepressant efficacy of accelerated bilateral TBS applied at 80% or 120% of the resting motor threshold (RMT) and left-sided 10 Hz rTMS applied at 120% RMT [4]. The increasing evidence base supporting TBS's antidepressant effects has seen it gain acceptance as an alternative to standard left-sided 10 Hz rTMS in treatment-resistant depression (TRD). Little is known whether TRD patients who do not experience antidepressant benefits with a standard course of rTMS might do so with a subsequent course of TBS, or vice-versa. Given that approximately 60–80% of patients who undergo a course of left-sided 10 Hz rTMS can expect to experience depression treatment response [3,5], this is a clinically relevant knowledge gap for which minimal evidence-based guidance exists. One way to address this is to evaluate non-responders’ treatment outcomes to a crossover course of the alternate stimulation protocol. To our knowledge, such a crossover study has not been reported.
DOI: 10.1016/j.brs.2022.06.005
PubMed URL:
ISSN: 1935-861X
Journal Title: Brain Stimulation
Type: Letter
Affiliated Organisations: Monash Alfred Psychiatry Research Centre, Department of Psychiatry, Monash University, Melbourne, Victoria, Australia
Bangkok Hospital, Bang Kapi, Bangkok, Thailand
The Adelaide Clinic, Ramsay Health Care (SA) Mental Health Services, South Australia, Australia
Discipline of Psychiatry, The University of Adelaide, South Australia, Australia; Northern Adelaide Local Health Network, South Australia, Australia
Appears in Collections:Mental Health

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