Please use this identifier to cite or link to this item: http://hdl.handle.net/11434/2096
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dc.contributor.authorSpitz, Gershon-
dc.contributor.authorHicks, Amelia-
dc.contributor.authorRoberts, Caroline-
dc.contributor.authorPonsford, Jennie-
dc.contributor.otherRowe, Christopher-
dc.date.accessioned2022-06-29T05:02:49Z-
dc.date.available2022-06-29T05:02:49Z-
dc.date.issued2022-05-10-
dc.identifier.citationv.35; 2022en_US
dc.identifier.issn2213-1582en_US
dc.identifier.urihttp://hdl.handle.net/11434/2096-
dc.description.abstractTraumatic brain injury (TBI) is associated with greater 'brain age' that may be caused by atrophy in grey and white matter. Here, we investigated 'brain age' in a chronic TBI (≥10 years) sample. We examined whether 'brain age' increases with years post injury, and whether it is associated with injury severity, cognition and functional outcome. We recruited 102 participants with moderate to severe TBI aged between 40 and 85 years. TBI participants were assessed on average 22 years post-injury. Seventy-seven healthy controls were also recruited. Participants' 'brain age' was determined using T1-weighted MRI images. TBI participants were estimated to have greater 'brain age' compared to healthy controls. 'Brain age' gap was unrelated to time since injury or long-term functional outcome on the Glasgow Outcome Scale-Extended. Greater brain age was associated with greater injury severity measured by post traumatic amnesia duration and Glasgow Coma Scale. 'Brain age' was significantly and inversely associated with verbal memory, but unrelated to visual memory/ability and cognitive flexibility and processing speed. A longitudinal study is required to determine whether TBI leads to a 'one-off' change in 'brain age' or progressive ageing of the brain over time.en_US
dc.publisherElsevieren_US
dc.subjectTraumatic Brain Injuryen_US
dc.subjectTBIen_US
dc.subjectAgeingen_US
dc.subjectBrain Ageen_US
dc.subjectCognitionen_US
dc.subjectFunctional Outcomeen_US
dc.subjectMonash-Epworth Rehabilitation Research Centre, Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University.en_US
dc.subjectRehabilitation, Mental Health and Chronic Pain Clinical Instituteen_US
dc.titleBrain age in chronic traumatic brain injury.en_US
dc.typeJournal Articleen_US
dc.identifier.doi10.1016/j.nicl.2022.103039en_US
dc.identifier.journaltitleNeuroImage: Clinicalen_US
dc.description.pubmeduripubmed.ncbi.nlm.nih.gov/35580421/en_US
dc.description.affiliatesDepartment of Molecular Imaging and Therapy, Austin Health, Heidelberg, Australiaen_US
dc.description.affiliatesFlorey Department of Neuroscience and Mental Health, University of Melbourne, Parkville, Australiaen_US
dc.type.studyortrialCase Control Studiesen_US
dc.type.contenttypeTexten_US
Appears in Collections:Rehabilitation

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