Please use this identifier to cite or link to this item:
Title: Brain age in chronic traumatic brain injury.
Epworth Authors: Spitz, Gershon
Hicks, Amelia
Roberts, Caroline
Ponsford, Jennie
Other Authors: Rowe, Christopher
Keywords: Traumatic Brain Injury
Brain Age
Functional Outcome
Monash-Epworth Rehabilitation Research Centre, Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University.
Rehabilitation, Mental Health and Chronic Pain Clinical Institute
Issue Date: 10-May-2022
Publisher: Elsevier
Citation: v.35; 2022
Abstract: Traumatic brain injury (TBI) is associated with greater 'brain age' that may be caused by atrophy in grey and white matter. Here, we investigated 'brain age' in a chronic TBI (≥10 years) sample. We examined whether 'brain age' increases with years post injury, and whether it is associated with injury severity, cognition and functional outcome. We recruited 102 participants with moderate to severe TBI aged between 40 and 85 years. TBI participants were assessed on average 22 years post-injury. Seventy-seven healthy controls were also recruited. Participants' 'brain age' was determined using T1-weighted MRI images. TBI participants were estimated to have greater 'brain age' compared to healthy controls. 'Brain age' gap was unrelated to time since injury or long-term functional outcome on the Glasgow Outcome Scale-Extended. Greater brain age was associated with greater injury severity measured by post traumatic amnesia duration and Glasgow Coma Scale. 'Brain age' was significantly and inversely associated with verbal memory, but unrelated to visual memory/ability and cognitive flexibility and processing speed. A longitudinal study is required to determine whether TBI leads to a 'one-off' change in 'brain age' or progressive ageing of the brain over time.
DOI: 10.1016/j.nicl.2022.103039
PubMed URL:
ISSN: 2213-1582
Journal Title: NeuroImage: Clinical
Type: Journal Article
Affiliated Organisations: Department of Molecular Imaging and Therapy, Austin Health, Heidelberg, Australia
Florey Department of Neuroscience and Mental Health, University of Melbourne, Parkville, Australia
Type of Clinical Study or Trial: Case Control Studies
Appears in Collections:Rehabilitation

Files in This Item:
There are no files associated with this item.

Items in Epworth are protected by copyright, with all rights reserved, unless otherwise indicated.