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Title: Moderators of gene-outcome associations following traumatic brain injury.
Epworth Authors: Ponsford, Jennie
Carmichael, Jai
Hicks, Amelia
Other Authors: Spitz, Gershon
Gould, Kate Rachel
Keywords: APOE
Antagonistic Pleiotropy
Apolipoprotein E
Brain-Derived Neurotrophic Factor
Precision Medicine
Traumatic Brain Injury
Monash Epworth Rehabilitation Research Centre, Richmond, Victoria, Australia
Rehabilitation Medicine, Epworth HealthCare, Richmond, Victoria, Australia
Rehabilitation, Mental Health and Chronic Pain Clinical Institute
Neurosciences Clinical Institute, Epworth HealthCare, Victoria, Australia
Issue Date: Nov-2021
Publisher: Elsevier
Citation: Neurosci Biobehav Rev . 2021 Nov;130:107-124
Abstract: The field of genomics is the principal avenue in the ongoing development of precision/personalised medicine for a variety of health conditions. However, relating genes to outcomes is notoriously complex, especially when considering that other variables can change, or moderate, gene-outcome associations. Here, we comprehensively discuss moderation of gene-outcome associations in the context of traumatic brain injury (TBI), a common, chronically debilitating, and costly neurological condition that is under complex polygenic influence. We focus our narrative review on single nucleotide polymorphisms (SNPs) of three of the most studied genes (apolipoprotein E, brain-derived neurotrophic factor, and catechol-O-methyltransferase) and on three demographic variables believed to moderate associations between these SNPs and TBI outcomes (age, biological sex, and ethnicity). We speculate on the mechanisms which may underlie these moderating effects, drawing widely from biomolecular and behavioural research (n = 175 scientific reports) within the TBI population (n = 72) and other neurological, healthy, ageing, and psychiatric populations (n = 103). We conclude with methodological recommendations for improved exploration of moderators in future genetics research in TBI and other populations.
DOI: 10.1016/j.neubiorev.2021.08.015
PubMed URL:
ISSN: 1873 7528
0149 7634
Journal Title: Neuroscience & Biobehavioral Reviews
Type: Journal Article
Affiliated Organisations: urner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Clayton, Australia
Type of Clinical Study or Trial: Narrative Reviews
Appears in Collections:Neurosciences

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