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Title: A novel application of [18F] fluorothymidine-PET ([18F]FLT-PET) in clinical practice to quantify regional bone marrow function in a patient with treatment-Induced cytopenias and to guide "marrow-sparing" radiotherapy.
Epworth Authors: Prince, Miles
Other Authors: Campbell, Belinda
Hofman, Michael
Keywords: [18F]Fluorothymidine-PET ([18F]FLT-PET)
Regional Bone Marrow Function
Treatment-Induced Cytopenias
Marrow-Sparing Radiotherapy
F-Fluorothymidine-Positron Emission Tomography
CT Fusion
Three-Dimensional Localization
Quantification of Functional Bone Marrow
Marrow Toxicity
Transformed Lymphoma
Treatment-Induced Cytopenias
Bone Marrow Reserve
Radiotherapy-Induced Bone Marrow Suppression
Epworth Centre for Immunotherapies and Snowdome Laboratories
Molecular Oncology and Cancer Immunology
Cancer Services Clinical Institute, Epworth HealthCare, Victoria, Australia
Issue Date: Nov-2020
Publisher: Lippincott Williams and Wilkins Ltd.
Citation: Clin Nucl Med. 2019 Nov;44(11):e624-e626.
Abstract: F-Fluorothymidine-positron emission tomography with CT fusion ([F]FLT-PET/CT) offers a unique and non-invasive method for three-dimensional localization and quantification of functional bone marrow. [F]FLT-PET/CT has potential application in radiotherapy planning when risk of marrow toxicity is a significant clinical concern. In this patient with chemo-refractory, transformed lymphoma and treatment-induced cytopenias, [F]FLT-PET/CT was a novel and useful adjunct to (1) image the distribution of functional bone marrow reserve, (2) guide "marrow-sparing" radiotherapy planning, and (3) quantify the effects of radiotherapy-induced bone marrow suppression both in-field and out-of-field.
DOI: 10.1097/RLU.0000000000002785
PubMed URL:
ISSN: 03639762
Journal Title: Clinical Nuclear Medicine
Type: Journal Article
Affiliated Organisations: Centre of Molecular Imaging, Peter MacCallum Cancer Centre, Melbourne, Victoria.
Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia.
Type of Clinical Study or Trial: Clinical Trial
Appears in Collections:Cancer Services

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