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Title: Clinical activity of TG-1701, as monotherapy and in combination with Ublituximab and Umbralisib (U2), in patients with B-cell malignancies.
Epworth Authors: Yannakou, Costas
Other Authors: Chan, Cheah
Wickham, Nick
Jurczak, Wojciech
Lasica, Masa
Wrobel, Tomasz
Lewis, Katharine
Długosz-Danecka, Monika
Giannopoulos, Krzysztof
Miskin, Hari
Tang, Jian-Ping
Normant, Emmanuel
Ricart, Alejandro
O'Connor, Owen
Tam, Constantine
Keywords: TG-1701 Monotherapy
Bruton’s Tyrosine Kinase Inhibitor
BTK Inhibitor
Immune Response
Treatment Naïve
Dose Escalation
Lymphocytic Leukemia
Mantle Cell Lymphoma
Waldenström's Macroglobulinemia
B-Cell Malignancies
Epworth Centre for Immunotherapies and Snowdome Laboratories
Department of Molecular Oncology and Cancer Immunology, Epworth HealthCare, East Melbourne, Victoria.
Cancer Services Clinical Institute, Epworth HealthCare, Victoria, Australia
Issue Date: Jul-2020
Conference Name: 62nd ASH Annual Meeting & Exposition
Conference Location: Georgia World Congress Center, Atlanta, Georgia, United States
Abstract: Introduction TG-1701 is a covalent Bruton’s tyrosine kinase (BTK) inhibitor with improved selectivity when compared with ibrutinib. Of note, the combination of TG-1701 with “U2” (the glycoengineered anti-CD20 monoclonal antibody ublituximab and the PI3Kδ-CK1ε dual inhibitor umbralisib) reduced the tumor growth of ibrutinib sensitive (REC1) and ibrutinib resistant (UPN-1res) mouse models of mantle cell lymphoma (MCL). TG-1701 combined with U2 increased infiltration of macrophages and NK cells promoting thereby immune response in the tumor microenvironment (Abstr 2205, AACR 2020). Herein we report clinical data of TG-1701 monotherapy and TG-1701 in combination with U2. Methods Patients with a range of relapsed/refractory (R/R) or treatment naïve (TN) B-cell malignancies were enrolled to an ongoing Phase 1 study first evaluating escalating doses of oral TG-1701 once daily (QD), continuously administered in 28-day cycles (100, 200, 300, and 400 mg). After characterizing the safety profile of TG-1701 monotherapy, we opened a parallel dose escalation (DE) arm of TG-1701 plus U2 (1701+U2). Select dose levels of TG-1701 monotherapy were also expanded to better characterize safety and efficacy in patients with chronic lymphocytic leukemia (CLL), MCL and Waldenström's macroglobulinemia (WM). All patients were treated until disease progression, unacceptable toxicity, or investigator/patient decision to withdraw. Results As of 21 July 2020, 102 patients have been treated with TG-1701 as follows: 25 in the monotherapy DE arm, 56 in the 200 mg QD expansion cohort (20 CLL [5 TN], 19 MCL [2 TN], 17 WM [7 TN], 7 in the 300 mg QD expansion cohort [all R/R CLL]), and 14 in the 1701+U2 DE arm (all R/R). Patients in the DE arms and expansion cohorts had a median of 1 prior systemic therapy (range, 1 – 10). The median durations of treatment exposure were 12 months (range, 1 – 24) on monotherapy DE, 4.6 months (range, 1 – 10) in the 200 mg expansion, and 12 months (range, 1 – 16) on 1701+U2. TG-1701 was well tolerated and the maximum tolerated dose was not reached up through 400 mg QD, with DE proceeded until 3 dose levels above complete BTK occupancy (≥ 99% occupancy observed at 100 mg QD). One dose-limiting toxicity was observed, a grade (G)3 ALT increased at 400 mg QD monotherapy. This event was transient, the patient remained asymptomatic with normal liver function, and continued treatment at a reduced dose of 300 mg QD. The most common G≥3 treatment-related adverse events (TRAE) were neutropenia (5%) on monotherapy, and neutropenia and ALT/AST increased for 1701+U2 (both 21%). There were no G4 TRAE with TG-1701 monotherapy. Among all-causality AEs of special interest, atrial fibrillation occurred in 4 patients (4%), G≥3 hypertension occurred in 1 patient (1%), and bleeding events (e.g. bruising, petechiae) occurred in 22 patients (22%, all G1-2). No cases of ventricular tachyarrhythmia have been reported. There have been no treatment-related deaths nor treatment discontinuations due to AEs. Linear kinetics are apparent, evidenced by approximately dose proportional increase in exposure. With a median follow up of 4.6 months in the 200 mg QD monotherapy expansion cohorts, preliminary overall response rates (ORR) were: 85% (17/20) in CLL, 42% (5/12) in MCL, and 86% (12/14) in WM. No complete responses (CR) were confirmed on TG-1701 monotherapy. The ORR for 1701+U2 was 85% (11/13, including 1/1 WM, 3/3 CLL, 4/6 FL, 2/2 MZL, and 1/1 DLBCL) with a 23% CR rate. Best change from baseline in tumor burden and response duration for patients in the 1701+U2 combination are presented in Figure 1. Conclusions TG-1701 was safe and effective in patients with B-cell malignancies and demonstrated near 100% saturation of the BTK at all dose levels studied. Monotherapy shows a low incidence of off-target adverse events. The combination of 1701+U2 has shown promising clinical activity and enhanced depth of response over TG-1701 monotherapy with no additional toxicity in patients with B-cell malignancy. Recruitment to this study (NCT03671590) continues.
Type: Conference Poster
Affiliated Organisations: Linear Clinical Research, Department of Haematology, Sir Charles Gairdner Hospital, Nedlands Western Australia
Medical School, University of Western Australia, Crawley, Western Australia
Ashford Cancer Centre Research, Adelaide, South Australia
Mara Sklodowska-Curie National Research Institute of Oncology, Krakow, Poland
St. Vincent's Hospital, Melbourne, Victoriis
University of Melbourne, Parkville, Victoria
Wroclaw Medical University, Poland
Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland
Hematology Department, St John’s Cancer Centre, Lublin, Poland
TG Therapeutics, Inc. New York, N.Y.
Medical Univ. of Lublin, Lublin, Poland
Type of Clinical Study or Trial: Clinical Trial
Appears in Collections:Cancer Services

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