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Title: Advances in frontline management of peripheral T-cell lymphoma.
Epworth Authors: Abeyakoon, Chathuri
Harrop, Sean
Yannakou, Costas
Prince, Miles
Other Authors: van der Weyden, Carrie
Khot, Amit
Dickinson, Michael
Keywords: Disease Monitoring
Hematopoietic Stem Cell Transplantation
Molecular Diagnostics
Novel Agents
Department of Haematology, Epworth HealthCare, Melbourne, Victoria, Australia
Cancer Services Clinical Institute, Epworth HealthCare, Victoria, Australia
Issue Date: Jun-2021
Publisher: Elsevier
Citation: Volume 21, Issue 6, June 2021, Pages 368-378
Abstract: Peripheral T-cell lymphomas (PTCLs) are a heterogeneous group of lymphomas that are frequently associated with a poor prognosis. For many decades, the standard-of-care has been CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisolone)-based therapy, but it is well-recognized that survival outcomes are unsatisfactory, especially when compared with B-cell lymphomas. Major recent advances in cancer diagnosis and management have the potential to significantly improve PTCL outcomes. These include: (1) improved diagnostic techniques that incorporate molecular genetic data to further refine diagnosis and subtyping; (2) the development of novel agents; and (3) improved monitoring modalities, such as <sup>18</sup>F-fluorodeoxyglucose positron emission tomography-computed tomography scans and circulating tumor DNA. In this review, we aim to explore these 3 advances in the context of frontline management of PTCL.
DOI: 10.1016/j.clml.2021.01.012
PubMed URL:
ISSN: 2152-2650
Journal Title: Clinical Lymphoma, Myeloma & Leukemia
Type: Journal Article
Affiliated Organisations: Department of Haematology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
Sir Peter MacCallum Department of Oncology, University of Melbourne, Victoria, Australia
Department of Haematology, Royal Melbourne Hospital, Melbourne, Victoria, Australia
Type of Clinical Study or Trial: Review
Appears in Collections:Cancer Services

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