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http://hdl.handle.net/11434/1950
Title: | Optimizing care for younger women with hormone receptor‐positive, HER2‐negative metastatic breast cancer. |
Epworth Authors: | De Boer, Richard |
Other Authors: | Hui, Rina Lim, Elgene Yeo, Belinda Zdenkowski, Nicholas |
Keywords: | CDK4/6 inhibitor HER2-negative Endocrine Therapy Hormone Receptor-positive Metastatic Breast Cancer Breast Neoplasms Psychosocial Multidisciplinary Care Younger Women Premenopausal Women Perimenopausal Women Supportive Care Receptors, Estrogen Cancer Services Clinical Institute, Epworth HealthCare, Victoria, Australia |
Issue Date: | Nov-2020 |
Publisher: | Wiley |
Citation: | Asia Pac J Clin Oncol . 2020 Nov;16 Suppl 5:3-14 |
Abstract: | Treatment strategies for hormone receptor‐positive (HR+), human epidermal growth factor receptor 2‐negative (HER2–) metastatic breast cancer in young women (<40 years at diagnosis) have traditionally been extrapolated from data obtained from trials conducted either exclusively or predominantly in the postmenopausal setting. These young patients are usually treated with ovarian function suppression (OFS) + endocrine therapy (ET) ± targeted therapy, except if there is a concern about endocrine resistance or a need to gain rapid disease control due to the onset of visceral crisis. This review examines evidence that supports the use of a cyclin‐dependent kinase 4/6 inhibitor, in combination with OFS and ET, when treating premenopausal or perimenopausal women with HR+/HER2– metastatic breast cancer. This includes data from the MONALEESA‐7 study (treating only premenopausal/perimenopausal women in the first‐line setting), and the results of subgroup analyses from the PALOMA‐3 and MONARCH‐2 trials. We also consider a number of age‐specific challenges that younger breast cancer patients can face, highlighting the importance of a multidisciplinary approach to ongoing care. |
URI: | http://hdl.handle.net/11434/1950 |
DOI: | 10.1111/ajco.13461 |
PubMed URL: | https://pubmed.ncbi.nlm.nih.gov/33137857/ |
ISSN: | 1743-7563 |
Journal Title: | Asia-Pacific Journal of Clinical Oncology |
Type: | Journal Article |
Affiliated Organisations: | University of Sydney, Camperdown, Sydney, New South Wales, Australia Westmead Hospital, Westmead, Sydney, New South Wales, Australia St. Vincent's Clinical School, University of New South Wales, Darlinghurst, Sydney, New South Wales, Australia Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales, Australia Austin Health, Heidelberg, Melbourne, Victoria, Australia Olivia Newton‐John Cancer Research Institute, Heidelberg, Melbourne, Victoria, Australia University of Newcastle, Newcastle, New South Wales, Australia Lake Macquarie Private Hospital, Gateshead, New South Wales, Australia Breast Cancer Trials, Newcastle, New South Wales, Australia |
Type of Clinical Study or Trial: | Review |
Appears in Collections: | Cancer Services |
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