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Title: Subacute sleep disturbance in moderate to severe traumatic brain injury: a systematic review
Epworth Authors: Fedele, Bianca
Williams, Gavin
McKenzie, Dean
Sutherland, Edwina
Olver, John
Keywords: Subacute Sleep Distrubance
Sleep Wake Disorders
Traumatic Brain Injury
Post Traumatic Amnesia
Sleep Disturbance
Subacute Care
Department of Rehabilitation, Epworth HealthCare, Melbourne, Australia.
Department of Rehabilitation, Epworth Monash Rehabilitation Medicine Unit (EMReM), Melbourne, Australia.
Research Development and Governance Unit, Epworth HealthCare, Melbourne, Australia.
Rehabilitation, Mental Health and Chronic Pain Clinical Institute
Neurosciences Clinical Institute, Epworth HealthCare, Victoria, Australia
Issue Date: Nov-2019
Publisher: Taylor and Francis
Citation: Brain Injury 2019 Nov 27:1-12
Abstract: Objective: This systematic review evaluated subacute sleep disturbance following moderate to severe traumatic brain injury (TBI) and the impact of secondary factors such as mood or pain.Methods: A comprehensive search strategy was applied to nine databases. Inclusion criteria included: adults ≥18 years, moderate and severe TBI and within 3 months of injury. Eligible studies were critically appraised using the McMaster Quantitative Critical Review Form. Study characteristics, outcomes, and methodological quality were synthesized. This systematic review was registered with PROSPERO (Registration number: CRD42018087799).Results: Ten studies were included. Research identified early-onset sleep disturbances; characterized as fragmented sleep periods and difficulty initiating sleep. Alterations to sleep architecture (e.g. rapid eye movement sleep) were reported. Sleep disturbance appears to associate with alterations of consciousness. Sleep disturbance tended to be particularly increased during the phase of post-traumatic amnesia (PTA) (78.7%).Conclusions: There is a limited amount of research available, which has inherent measurement and sample size limitations. The gold standard for measuring sleep (polysomnography) was rarely utilized, which may affect the detection of sleep disturbance and sleep architecture. Secondary factors potentially influencing sleep were generally not reported. Further evaluation on associations between sleep and PTA is needed.
PubMed URL:
ISSN: 0269-9052
Journal Title: Brain Injury
Type: Journal Article
Affiliated Organisations: School of Clinical Sciences, Monash University, Melbourne, Australia.
Department of Physiotherapy, The University of Melbourne, Melbourne, Australia.
Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia.
Type of Clinical Study or Trial: Systematic Reviews
Appears in Collections:Neurosciences

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