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Title: Molecular drivers of breast implant-associated anaplastic large cell lymphoma
Epworth Authors: Blombery, Piers
Prince, Miles
Other Authors: Thomas, E. R.
Keywords: Breast Implant
Anaplastic Large Cell Lymphoma
Breast Implant Associated Anaplastic Large Cell Lymphoma
T-Cell Lymphoproliferative Disorder
Genomic Characterization
Molecular Abnormalities
ALK-Negative Systemic Anaplastic Large Cell Lymphoma
JAK/STAT Activation
MYC/TP53 Dysregulation
High-Throughput Sequencing
Issue Date: Mar-2019
Publisher: Wolters Kluwer
Citation: Plast Reconstr Surg. 2019 Mar;143(3S A Review of Breast Implant-Associated Anaplastic Large Cell Lymphoma):59S-64S. doi: 10.1097/PRS.0000000000005570
Abstract: Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a rare T-cell lymphoproliferative disorder occurring in patients with breast implants. Genomic characterization performed in BIA-ALCL to date has demonstrated qualitatively similar molecular abnormalities to those seen in its more common counterpart [ALK-negative systemic anaplastic large cell lymphoma (sALCL)] including JAK/STAT activation and MYC/TP53 dysregulation. Despite these observed similarities at the molecular level, the outcomes of sALCL and BIA-ALCL are markedly different with sALCL typically associated with an aggressive course and inferior outcomes compared with BIA-ALCL. This review describes the findings of high-throughput sequencing and other genomic characterization to date in BIA-ALCL and the insights these studies have given into the molecular drivers of this rare lymphoma subtype.
DOI: 10.1097/PRS.0000000000005570
PubMed URL:
ISSN: 0032-1052
Journal Title: Plastic and Reconstructive Surgery
Type: Journal Article
Affiliated Organisations: Parkville and East Melbourne, Victoria, Australia From the Department of Pathology
Peter MacCalllum Cancer Centre, University of Melbourne
Sir Peter MacCallum Department of Oncology, University of Melbourne
Appears in Collections:General Surgery and Gastroenterology

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