Please use this identifier to cite or link to this item: http://hdl.handle.net/11434/1275
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dc.contributor.authorJolly, David-
dc.contributor.authorDunn, Leon-
dc.contributor.authorKenny, John-
dc.date.accessioned2017-11-29T02:07:35Z-
dc.date.available2017-11-29T02:07:35Z-
dc.date.issued2017-01-
dc.identifier.citationJ Appl Clin Med Phys. 2017 Jan;18(1):59-65en_US
dc.identifier.issn1526-9914en_US
dc.identifier.urihttp://hdl.handle.net/11434/1275-
dc.description.abstractIn radiation therapy, calculation of dose within the patient contains inherent uncertainties, inaccuracies, limitations, and the potential for random error. Thus, point dose-independent verification of such calculations is a well-established process, with published data to support the setting of both action levels and tolerances. Mobius3D takes this process one step further with a full independent calculation of patient dose and comparisons of clinical parameters such as mean target dose and voxel-by-voxel gamma analysis. There is currently no published data to directly inform tolerance levels for such parameters, and therefore this work presents a database of 1000 Mobius3D results to fill this gap. The data are tested for normality using a normal probability plot and found to fit this distribution for three sub groups of data; Eclipse, iPlan and the treatment site Lung. The mean (μ) and standard deviation (σ) of these sub groups is used to set action levels and tolerances at μ ± 2σ and μ ± 3σ, respectively. A global (3%, 3 mm) gamma tolerance is set at 88.5%. The mean target dose tolerance for Eclipse data is the narrowest at ± 3%, whilst iPlan and Lung have a range of -5.0 to 2.2% and -1.8 to 5.0%, respectively. With these limits in place, future results failing the action level or tolerance will fall within the worst 5% and 1% of historical results and an informed decision can be made regarding remedial action prior to treatment.en_US
dc.publisherWileyen_US
dc.relation.urihttp://onlinelibrary.wiley.com/doi/10.1002/acm2.12009/full-
dc.subjectRadiation Therapyen_US
dc.subjectMobius3Den_US
dc.subjectPatient Doseen_US
dc.subjectEclipseen_US
dc.subjectiPlanen_US
dc.subjectLungen_US
dc.subjectLimitationsen_US
dc.subjectTolerance Levelsen_US
dc.subjectAction Levelen_US
dc.subjectDatabaseen_US
dc.subjectIndependent Verificationen_US
dc.subjectVerifcation Programsen_US
dc.subjectClinical Decision Makingen_US
dc.subjectTreatment Planningen_US
dc.subjectEpworth Radiation Oncology Research Centre, Epworth HealthCare, Melbourne, VIC, Australia.en_US
dc.subjectCancer Services Clinical Institute, Epworth HealthCare, Victoria, Australiaen_US
dc.titleA clinical database to assess action levels and tolerances for the ongoing use of Mobius3D.en_US
dc.typeJournal Articleen_US
dc.identifier.doi10.1002/acm2.12009en_US
dc.identifier.journaltitleJournal of Applied Clinical Medical Physicsen_US
dc.description.pubmedurihttps://www.ncbi.nlm.nih.gov/pubmed/28291923en_US
dc.type.studyortrialValidation Studyen_US
dc.type.contenttypeTexten_US
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