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Title: Extracellular vesicles for personalized therapy decision support in advanced metastatic cancers and its potential impact for prostate cancer.
Epworth Authors: Corcoran, Niall
Other Authors: Soekmadji, Carolina
Oleinikova, Irena
Jovanovic, Lidija
Ramm, Grant
Nelson, Colleen
Jenster, Guido
Russell, Pamela
Australian Prostate Cancer Collaboration BioResource
Keywords: Biomarkers
Circulating Tumor Cells
Extracellular Vesicles
Prostate Cancer
Metastatic Prostate Cancer
Personalized Therapy
Australian Prostate Cancer Research Centre Epworth HealthCare, Victoria, Australia
Issue Date: Aug-2017
Publisher: Wiley
Citation: Prostate. 2017 Aug 29
Abstract: The use of circulating tumor cells (CTCs) and circulating extracellular vesicles (EVs), such as exosomes, as liquid biopsy-derived biomarkers for cancers have been investigated. CTC enumeration using the CellSearch based platform provides an accurate insight on overall survival where higher CTC counts indicate poor prognosis for patients with advanced metastatic cancer. EVs provide information based on their lipid, protein, and nucleic acid content and can be isolated from biofluids and analyzed from a relatively small volume, providing a routine and non-invasive modality to monitor disease progression. Our pilot experiment by assessing the level of two subpopulations of small EVs, the CD9 positive and CD63 positive EVs, showed that the CD9 positive EV level is higher in plasma from patients with advanced metastatic prostate cancer with detectable CTCs. These data show the potential utility of a particular EV subpopulation to serve as biomarkers for advanced metastatic prostate cancer. EVs can potentially be utilized as biomarkers to provide accurate genotypic and phenotypic information for advanced prostate cancer, where new strategies to design a more personalized therapy is currently the focus of considerable investigation.
DOI: 10.1002/pros.23403
PubMed URL:
ISSN: 1097-0045
Journal Title: The Prostate
Type: Journal Article
Affiliated Organisations: Department of Cell and Molecular Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia
Department of Urology, Queensland Health, Princess Alexandra Hospital, Brisbane, Queensland, Australia
Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia
Translational Research Institute, Brisbane, Queensland, Australia
Australian Prostate Cancer Collaboration (APCC) Bioresource, Brisbane, Queensland, Australia
Department of Urology, Erasmus Medical Centre, R,otterdam, The Netherlands
Department of Surgery, University of Melbourne, Australia
Type of Clinical Study or Trial: Review
Appears in Collections:Cancer Services

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