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Title: The impact of disability in survivors of critical illness.
Epworth Authors: Barrett, Jonathan
Hunt-Smith, Julian
Ponsford, Jennie
Other Authors: Hodgson, Carol
Udy, Andrew
Bailey, Michael
Bellomo, Rinaldo
Bucknall, Tracey
Gabbe, Belinda
Higgins, Alisa
Iwashyna, Theodore
Murray, Lynne
Myles, Paul
Pilcher, David
Walker, Craig
Young, Meredith
Cooper, D.J.
Keywords: Intensive Care Unit
Mechanical Ventilation
Quality of Life
Post Intensive Care Syndrome
Limitation in Activites
World Health Organisation's International Classification of Functioning
World Health Organisation's Disability Assessment Schedule 2.0
Patient-Reported Outcomes
Multicenter Study
Critical Illness
Critical Care Clincial Institute, Epworth HealthCare, Victoria, Australia
Monash-Epworth Rehabilitation Research Centre, Epworth HealthCare, Melbourne, Australia
Issue Date: Jul-2017
Publisher: Springer
Citation: Intensive Care Med. 2017 Jul;43(7):992-1001
Abstract: PURPOSE: To use the World Health Organisation's International Classification of Functioning to measure disability following critical illness using patient-reported outcomes. METHODS: A prospective, multicentre cohort study conducted in five metropolitan intensive care units (ICU). Participants were adults who had been admitted to the ICU, received more than 24 h of mechanical ventilation and survived to hospital discharge. The primary outcome was measurement of disability using the World Health Organisation's Disability Assessment Schedule 2.0. The secondary outcomes included the limitation of activities and changes to health-related quality of life comparing survivors with and without disability at 6 months after ICU. RESULTS: We followed 262 patients to 6 months, with a mean age of 59 ± 16 years, and of whom 175 (67%) were men. Moderate or severe disability was reported in 65 of 262 (25%). Predictors of disability included a history of anxiety/depression [odds ratio (OR) 1.65 (95% confidence interval (CI) 1.22, 2.23), P = 0.001]; being separated or divorced [OR 2.87 (CI 1.35, 6.08), P = 0.006]; increased duration of mechanical ventilation [OR 1.04 (CI 1.01, 1.08), P = 0.03 per day]; and not being discharged to home from the acute hospital [OR 1.96 (CI 1.01, 3.70) P = 0.04]. Moderate or severe disability at 6 months was associated with limitation in activities, e.g. not returning to work or studies due to health (P < 0.002), and reduced health-related quality of life (P < 0.001). CONCLUSION: Disability measured using patient-reported outcomes was prevalent at 6 months after critical illness in survivors and was associated with reduced health-related quality of life. Predictors of moderate or severe disability included a prior history of anxiety or depression, separation or divorce and a longer duration of mechanical ventilation.
DOI: 10.1007/s00134-017-4830-0
PubMed URL:
ISSN: 0342-4642
Journal Title: Intensive Care Medicine
Type: Journal Article
Affiliated Organisations: Australian and New Zealand Intensive Care Research Centre, Melbourne, Australia.
The Alfred Hospital, Melbourne, Australia.
Monash University, Melbourne, Australia.
Monash Partners Academic Health Science Centre, Prahran, Australia.
Cabrini Hospital, Melbourne, Australia.
Austin Health, Melbourne, Australia.
Deakin University, Geelong, Australia.
University of Michigan, Michigan, USA.
Monash Medical Centre, Melbourne, Australia.
Type of Clinical Study or Trial: Prospective Cohort Study
Appears in Collections:Critical Care
Mental Health

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