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Title: Outcome of ultrasound-guided sclerotherapy for varicose veins: medium-term results assessed by ultrasound surveillance.
Authors: Myers, Ken
Clough, Anthony
Other Authors: Jolley, D.
Kirwan, J.
Keywords: Ultrasound-guided Sclerotherapy
Superficial Chronic Venous Ddisease
Varicose Veins
Saphenous Vein
Saphenous Reflux
Chronic Disease
Kaplan-Meier Estimate
Life Tables
Age Distribution
Patient Selection
Proportional Hazards Models
Prospective Studies
Risk Factors
Follow-Up Studies
Diagnostic Imaging
Adverse Effects
Time Factors
Treatment Outcome
Venous Thrombosis
Melbourne Vascular Ultrasound, Epworth Hospital, Victoria, Australia
UroRenal, Vascular Clinical Institute, Epworth HealthCare, Victoria, Australia
Issue Date: Jan-2007
Publisher: European Society for Vascular Surgery, Elsevier
Citation: 2007 Jan;33(1):116-21.
Abstract: OBJECTIVE: To estimate medium-term success after a technique for ultrasound-guided sclerotherapy for superficial chronic venous disease. DESIGN: A prospective study in a single unit with ultrasound surveillance after treatment. MATERIALS: Results after 1189 treatment sessions for 807 venous saphenous veins and related tributaries or non-saphenous tributaries in 489 patients. METHODS: Univariate life table analysis determined primary and secondary success rates. Multivariate Cox regression analysis detected covariates that affected outcome. RESULTS: Primary and secondary success rates at 36 months for all veins were 52.4% (95%CI 46-58%) and 76.8% (95%CI 71-82%). Cox regression analysis for primary success for all veins showed significantly worse results for saphenous veins compared to tributaries (HR 3.72 - 95%CI 1.9 to 7.3). Cox regression for all saphenous veins showed independently worse results for patients less than 40 years age (HR 2.16 - 95%CI 1.27-3.66), small compared to great saphenous veins (HR 1.58 - 95%CI 1.11-2.24), veins greater than 6mm diameter compared to smaller veins (HR 2.22 - 95%CI 1.40-3.50), liquid compared to foam sclerotherapy (HR 2.20 - 95%CI 1.28-3.78), lower volumes of sclerosant compared to volumes greater than 12 ml (HR 0.51 - 95%CI 0.33-0.81) and highly diluted compared to concentrated sclerosant (HR 2.05 - 95%CI 1.21-3.46) with worse results using highly diluted or undiluted 3% sclerosant compared to a 1.5% concentration. There were no significant differences for primary success for saphenous veins for date of procedure, sex, side, primary or recurrent varicose veins, or commercial type of sclerosant. CONCLUSIONS: Ultrasound-guided sclerotherapy gives satisfactory results if it is accepted that treatment may need to be repeated to achieve secondary success. Results provide a basis for further research to explore factors that might affect outcome. Younger patients with larger diameter saphenous veins may warrant alternative forms of treatment, particularly for small saphenous reflux.
DOI: 10.1016/j.ejvs.2006.09.005
PubMed URL:
ISSN: 1078-5884
Journal Title: European Journal of Vascular and Endovascular Surgery
Type: Journal Article
Type of Clinical Study or Trial: Prospective Cohort Study
Appears in Collections:Diagnostic Services
UroRenal, Vascular

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