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Title: Zero hospital admissions for infection after 577 transperineal prostate biopsies using single-dose cephazolin prophylaxis.
Authors: Frydenberg, Mark
Moon, Daniel
Landau, Adam
Grummet, Jeremy
Other Authors: Pepdjonovic, Lana
Tan, Guan Hee
Huang, Sean
Mann, Sarah
Hanegbi, Uri
Snow, Ross
Keywords: Antibiotic Prophylaxis
Transperineal Biopsy
Infection Control
Transperineal Prostate Biopsy
Therapeutic Guidelines
Epworth Prostate Cancer Research Centre, Epworth HealthCare, Victoria, Australia
UroRenal, Vascular Clinical Institute, Epworth HealthCare, Victoria, Australia
Issue Date: Dec-2016
Publisher: Springer
Citation: World J Urol. 2016 Dec 16.
Abstract: PURPOSE: To determine the rate of hospital admissions for infection after transperineal biopsy of prostate (TPB) with single-dose cephazolin prophylaxis using a prospective database. METHOD: Between April 2013 and February 2016, 577 patients undergoing TPB had 2 g of cephazolin given intravenously at induction of anaesthesia. Data collected from these patients included age, PSA, prostate volume, number of cores taken and post-operative complications. RESULTS: No patients were readmitted to hospital with infection post-TPB. Seven patients developed acute urinary retention, and one patient developed clinical prostatitis that was treated with oral antibiotics in the community. CONCLUSION: It is safe to use single-dose cephazolin only as antibiotic prophylaxis prior to TPB, negating the need for quinolones. This study supports Australia's current Therapeutic Guidelines recommendation for TPB prophylaxis and the existing evidence that sepsis post-TPB is a rare complication. Whether any antibiotic prophylaxis is needed at all for TPB is the subject of a future study.
DOI: 10.1007/s00345-016-1985-1
PubMed URL:
ISSN: 1433-8726
Journal Title: World Journal of Urology
Type: Journal Article
Affiliated Organisations: Australian Urology Associates, Melbourne, Australia.
Urology Unit, Department of Surgery, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
Department of Urology, Alfred Health, Melbourne, Australia.
Department of Surgery, Monash University, Melbourne, Australia.
Type of Clinical Study or Trial: Prospective Study
Appears in Collections:Epworth Prostate Centre
UroRenal, Vascular

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