Please use this identifier to cite or link to this item: http://hdl.handle.net/11434/991
Title: Impact of apolipoprotein gene on cognitive impairment and recovery after traumatic brain injury.
Epworth Authors: Ponsford, Jennie
Other Authors: Rudzki, Dion
Bailey, Karen
Ng, Kim
Keywords: Adolescent
Adult
Apolipoprotein E4/genetics
Attention
Physiology
Brain Injuries
Complications
Genetics
Cognition Disorders
Diagnosis
Physiopathology
DNA Mutational Analysis
Disability Evaluation
Female
Gene Dosage
Genetic Predisposition to Disease
Genotype
Glasgow Coma Scale
Memory
Physiology
Memory Disorders
Diagnosis
Middle Aged
Neuropsychological Tests
Recovery of Function
Thinking
Apolipoprotein E4
Department of Psychology, Epworth Healthcare, Victoria
Monash-Epworth Rehabilitation Research Centre, Epworth Healthcare, Victoria, Australia.
Issue Date: Feb-2007
Publisher: Wolters Kluwer Lippincott Williams Wilkins.
Citation: Neurology. 2007 Feb 20;68(8):619-20
Abstract: The presence of the ε4 allele may have a negative influence on response to injury and recovery in patients with traumatic brain injury (TBI). However, no study to date has included an uninjured control group to examine whether the influence of the ε4 allele might be independent of TBI. In this study, we investigated whether presence of the ε4 allele in patients with TBI results in greater impairments of memory, attention, executive function, and functional outcome 3, 6, and 12 months postinjury, and in slower recovery, than in patients without the ε4 allele and uninjured controls. Methods. Following ethics approval and informed consent, 120 patients with moderate–severe TBI, aged 16 to 64 years, with no history of previous neurologic or psychiatric disorder were assessed 3, 6, and 12 months postinjury. They comprised 69.2% men, with mean Glasgow Coma Scale score (GCS) 8.24 (SD = 4.17, range = 3 to 15), mean post-traumatic amnesia (PTA) 26.14 days (SD = 28.64, range = <1 to 135), mean age 32.66 years (SD 13.38, range = 17 to 64), mean education 12.48 years (SD = 2.38, range = …
URI: http://hdl.handle.net/11434/991
DOI: 10.1212/01.wnl.0000254609.04330.9d
PubMed URL: https://www.ncbi.nlm.nih.gov/pubmed/17310037
ISSN: 0028-3878
Journal Title: Neurology
Type: Journal Article
Affiliated Organisations: Monash University, Melbourne, Australia.
Type of Clinical Study or Trial: Cohort Study
Appears in Collections:Neurosciences
Rehabilitation

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