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Title: Prospective longitudunal comparative study of long-term urinary and sexual function after primary surgical treatment for localized prostate cancer.
Authors: Zargar, Homayoun
Moon, Daniel
Frydenberg, Mark
Costello, Anthony
Botti, Mari
Keywords: Urology
Prostate Cancer
Robotic assisted
Radial Prostatectomy Surgery
Long Term Sexual Function
Prostatic Neoplasms
Urinary Function
Erectile Function
Poster 58
Epworth/Deakin Centre for Clinical Nursing Research, Deakin University, Melbourne, Australia.
Epworth Prostate Centre, Epworth HealthCare, Victoria, Australia.
​UroRenal & Vascular Clinical Institute, Epworth HealthCare, Victoria, Australia.
Issue Date: Jul-2016
Citation: Jul-2016, Poster 58
Conference Name: Epworth Research Institute Research Week 2016
Conference Location: Epworth, Richmond, Victoria, Australia.
Abstract: Introduction/Background: To prospectively and independently assess real world outcomes of Australian men's urinary and sexual function following retropubic (RRP), laparoscopic (LRP) and robotic assisted (RARP) radical prostatectomy surgery for localized prostate cancer. Methods: From 2009 to 2012 men with localized prostate cancer undergoing surgery by one of the fourteen urologists working across eight private-sector sites were included. Patients were consented and data was collected by self-reported questionnaires prospectively at 3,6,12,18 and 24 months by independent researchers. Urinary and sexual function data were obtained using EPIC, SHIM and IPSS questionnaires. Results: Overall 1005 men were recruited (participation rate of 79.2%), with 836 men having completed surveys at each follow-up. At 24 months follow-up the median EPIC urinary and sexual summary scores were at 95.6 and 47.4% of baseline respectively. The rate of erectile function preservation at 24 months in men with good erectile function preoperatively (SHIM≥ 20) was 27% for the entire cohort. On multivariable cox regression model (including age, Gleason score, prostate volume, preoperative SHIM score, surgical modality), age (OR 0.94 95% CI (0.91-0.97); p-0.001), preoperative erectile function (OR 1.26 95% CI (1.14-.41); p<0.001) and laparoscopic approach (OR 0.23 95% CI (0.09-0.60); p=0.002 were predictors of erectile function at 24 months. Conclusions: Surgical therapy for localized prostate cancer provides excellent long-term urinary function as measured by EPIC urinary summary score in our series. Long-term sexual function was less preserved as demonstrated by 24 months EPIC sexual summary score. The rate of sexual function preservation for men with good pre-existing sexual function treated by surgical therapy in this real world prospective independently collected community based study is far lower than previously reported by tertiary referral centres. The impact of surgeon's training and experience are likely to be important determiners of long-term sexual functions and will be addressed in the future studies.
Type: Conference Poster
Affiliated Organisations: Departments of Urology and Surgery, Royal Melbourne Hosiptal, Parkville, VIC, Australia.
Peter MacCallum Cancer Centre, Melbourne VIC, Australia.
Department of Surgery, Deaprtment of Urology, Monash University.
Type of Clinical Study or Trial: Cohort Study
Appears in Collections:Cancer Services

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