Please use this identifier to cite or link to this item: http://hdl.handle.net/11434/937
Title: Androgen synthesis in prostate cancer: do all roads lead to Rome?
Epworth Authors: Stuchbery, Ryan
Hovens, Christopher
Corcoran, Niall
Other Authors: McCoy, Patrick
Keywords: Prostate Cancer
Cancer Therapy
Pathways
Signalling Androgens
Androgen Synthesis
Adrenal Cortex Hormones
Hormone Receptors
Gonadal Hormones
Androgen-Deprivation Therapy
Dihydrotestosterone
Castration Resistance
Cancer Services Clinical Institute, Epworth HealthCare, Victoria, Australia
Australian Prostate Cancer Research Centre, Epworth HealthCare, Victoria, Australia
Issue Date: Nov-2016
Publisher: Springer Nature
Citation: Nat Rev Urol. 2017 Jan;14(1):49-58
Abstract: The accumulation of high concentrations of signalling androgens within prostate tumours that progress despite use of androgen-deprivation therapy is a clinically important mechanism of the development of castration-resistant prostate cancer. In the past 5 years, data from a number of studies have increased our understanding of the enzymes and substrates involved in intratumoural androgen biosynthesis, and have implicated three competing pathways, which are likely to account for these observations. These pathways ('canonical', 'backdoor' and '5α-dione'), which can all ultimately generate the potent signalling androgen, dihydrotestosterone, involve many of the same enzymes, but differ in terms of substrate preference, reaction sequence and the organs and tissues in which they occur. For this reason, the relative importance of each pathway to the development and progression of prostate cancer remains controversial. In this Review, we describe the current understanding of androgen synthesis and the evidence for its role in castration resistance, and examine the evidence supporting and or rebutting the relevance of each pathway to patients with prostate cancer.
URI: http://hdl.handle.net/11434/937
DOI: 10.1038/nrurol.2016.221
PubMed URL: https://www.ncbi.nlm.nih.gov/pubmed/27824348
ISSN: 1759-4812
1759-4820
Journal Title: Nature Reviews Urology
Type: Journal Article
Affiliated Organisations: Department of Surgery, Royal Melbourne Hospital, Parkville, Victoria, Australia.
Department of Urology, Royal Melbourne Hospital, Parkville, Victoria, Australia.
Department of Urology, Frankston Hospital, Frankston, Victoria, Australia.
Type of Clinical Study or Trial: Review
Appears in Collections:Cancer Services
UroRenal, Vascular
Epworth Prostate Centre

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