Please use this identifier to cite or link to this item: http://hdl.handle.net/11434/914
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dc.contributor.authorO'Sullivan, Richard-
dc.contributor.otherMaulana, R.-
dc.contributor.otherLiu, B.-
dc.contributor.otherFindlay, D.-
dc.contributor.otherWluka, Anita-
dc.contributor.otherCicuttini, Flavia-
dc.contributor.otherGiles, Graham-
dc.contributor.otherTeichtahl, Andrew-
dc.contributor.otherWang, Yuanyuan-
dc.date.accessioned2016-11-22T04:40:16Z-
dc.date.available2016-11-22T04:40:16Z-
dc.date.issued2015-09-
dc.identifier.citationArthritis Res Ther. 2015 Sep 27;17:270en_US
dc.identifier.issn1478-6362en_US
dc.identifier.urihttp://hdl.handle.net/11434/914-
dc.description.abstractINTRODUCTION: Bone marrow lesions (BMLs) are features detected on MRI that are important in the pathogenesis of knee osteoarthritis. Since BMLs reflect heterogeneous pathologies this prospective cohort study examined whether BMLs detected using different MRI sequences are associated with distinct structural and clinical endpoints. METHODS: A total of 297 community-based adults without knee pain were examined to identify BMLs visualised using three-dimensional T1-weighted gradient-echo fat-suppressed (T1-weighted sequences) fat-suppressed and fat-saturated FSE T2-weighted MRI sequences (T2-weighted sequences) at baseline. Cartilage volume was measured at baseline and follow-up, while incident knee pain was assessed at follow-up, an average of 2.3 years later. RESULTS: At baseline, 46 BMLs were visualised in 39 participants. Of the 45 BMLs visualised on T2-weighted sequences, 34 (74%) were also seen on T1-weighted sequences. One BML was seen on only T1-weighted sequences. Knees with BMLs visualised on both T1- and T2-weighted sequences had significantly higher medial tibial cartilage volume loss (45 mm3/annum, standard error of the mean (SEM) 14) than those with BMLs identified on only T2-weighted sequences (-13 mm3/annum SEM 19), after adjustment for age, gender and body mass index (p = 0.01). Incident knee pain was more likely in individuals with BMLs in the medial compartment visualised on both T1- and T2-weighted (eight participants, 53%) compared to those with BMLs on only T2-weighted sequences (0%) or no BMLs (76 participants, 31%, p = 0.02). CONCLUSIONS: BMLs present on both T1- and T2-weighted MRI sequences were associated with increased medial tibial cartilage loss and incident knee pain compared with those BMLs seen only on T2-weighted sequences. This suggests that combining different MRI sequences may provide more informative targets in the prevention and treatment of knee osteoarthritis.en_US
dc.publisherSpringeren_US
dc.subjectBMIen_US
dc.subjectBody Mass Indexen_US
dc.subjectPathogenesisen_US
dc.subjectOsteoarthritisen_US
dc.subjectKneeen_US
dc.subjectMRIen_US
dc.subjectMRI Sequencingen_US
dc.subjectBMLen_US
dc.subjectBone Marrow Lesionen_US
dc.subjectMagnetic Resonance Imagingen_US
dc.subjectBone Marrowen_US
dc.subjectLesionsen_US
dc.subjectMusculoskeletal Clinical Institute, Epworth HealthCare, Victoria, Australiaen_US
dc.subjectEpworth Medical Imaging, Victoria, Australiaen_US
dc.titleBone marrow lesions can be subtyped into groups with different clinical outcomes using two magnetic resonance imaging (MRI) sequences.en_US
dc.typeJournal Articleen_US
dc.identifier.doi10.1186/s13075-015-0780-5en_US
dc.identifier.journaltitleArthritis Research & Therapyen_US
dc.description.pubmedurihttps://www.ncbi.nlm.nih.gov/pubmed/26410822en_US
dc.description.affiliatesUniversity of Adelaide, Royal Adelaide Hospital, Adelaide, Australiaen_US
dc.description.affiliatesMonash University, Victoria, Australiaen_US
dc.description.affiliatesAlfred Hospital, Melbourne, Australiaen_US
dc.type.studyortrialProspective Cohort Studyen_US
dc.type.contenttypeTexten_US
Appears in Collections:Diagnostic Services
Musculoskeletal

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