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|Title:||Gleason pattern 4: active surveillance no more.|
|Epworth Authors:||Murphy, Declan|
|Other Authors:||Sathianathen, Niranjan|
Van den Bergh, Roderick
|Keywords:||Gleason Pattern 4|
Epworth Prostate Centre, Epworth Healthcare, Victoria, Australia
UroRenal, Vascular Clinical Institute, Epworth HealthCare, Victoria, Australia
|Abstract:||To reduce overtreatment of indolent prostate cancer (PCa), urologists have embraced active surveillance (AS) as a management strategy for low-risk PCa; however, patterns-of-care studies are now showing that AS is also being used for patients with intermediate-risk disease. A contemporary Australian study of 980 men reported that 8.9% of men with intermediate-risk disease were placed on AS, of whom 53.8% had Gleason score (GS) 3+4 PCa and 10.4% had GS 4+3 PCa . The most recent update from the CaPSURE database also reflected this trend in AS, but questions remain about the safety of this practice, particularly as the majority of AS protocols worldwide exclude men with GS 4 PCa, unless their life expectancy is limited.|
|Journal Title:||BJU International|
|Affiliated Organisations:||Division of Cancer Surgery, University of Melbourne, Victoria, Australia|
Department of Urology, Royal Melbourne Hospital, Victoria, Australia.
Faculty of Medicine, Monash University, Melbourne, Victoria, Australia.
Departments of Urology and Surgery, Royal Melbourne Hospital, Melbourne, Vic., Australia.
Department of Surgery, The Austin Hospital, Heidelberg, Victoria., Australia.
Olivia Newton-John Cancer Research Institute, Melbourne, Victoria, Australia.
|Type of Clinical Study or Trial:||Cohort Study|
|Appears in Collections:||Cancer Services|
Epworth Prostate Centre
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