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Title: Words of wisdom re: Chemohormonal therapy in metastatic hormone-sensitive prostate cancer.
Authors: Murphy, Declan
Other Authors: Zargar, Homayoun
Keywords: Prostate Cancer
Metastatic Prostate Cancer
Chemohormonal Therapy
Androgen Deprivation Therapy
Docetaxel Chemotherapy
Survival Rates
Australian Prostate Cancer Research Centre, Epworth HealthCare, Victoria, Australia
Cancer Services Clinical Institute, Epworth HealthCare, Victoria, Australia
Issue Date: 2016
Publisher: Elsevier
Citation: Eur Urol. 2016 Mar;69(3):540
Abstract: Experts’ summary: This landmark study of men with advanced prostate cancer tested the hypothesis that addition of docetaxel chemotherapy (DC) to androgen deprivation therapy (ADT) at the time of treatment initiation would lead to improved overall survival in men with metastatic prostate cancer (CHAARTED trial). A total of 790 men were randomised. At a median follow-up of 29 mo, overall survival was 13.6 mo longer in the ADT + DC group than for ADT alone (57.6 vs 44.0 mo; hazard ratio [HR] 0.61, 95% confidence interval [CI] 0.47–0.80; p < 0.001). Furthermore, among men with high-volume metastatic disease, the median overall survival was 17.0 mo longer in the ADT + DC group than for ADT alone (49.2 vs 32.2 mo; HR 0.60, 95% CI 0.45–0.81; p < 0.001). Overall, the combined treatment was quite well tolerated.
Description: Comment on Chemohormonal 'Therapy in Metastatic Hormone-Sensitive Prostate Cancer.'. Sweeney CJ, Chen YH, Carducci M, et al, N Engl J Med 2015;373:737–46.
DOI: doi: 10.1016/j.eururo.2015.12.027
PubMed URL:
ISSN: 0302-2838
Journal Title: European Urology
Type: Comment
Affiliated Organisations: Department of Urology, Royal Melbourne Hospital, Melbourne, Australia
Division of Cancer Surgery, Peter MacCallum Cancer Centre, University of Melbourne, Melbourne, Australia
Department of Urology, Royal Melbourne Hospital, Melbourne, Australia
Appears in Collections:Cancer Services
Epworth Prostate Centre
UroRenal, Vascular

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