Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorCohney, Solomon (Shlomo)-
dc.contributor.otherViecelli, A.-
dc.contributor.otherLim, W.-
dc.contributor.otherMacaskill, P.-
dc.contributor.otherChapman, J.-
dc.contributor.otherClayton, P.-
dc.contributor.otherCarroll, R.-
dc.contributor.otherWong, G.-
dc.identifier.citationTransplantation. 2015 Dec;99(12):2586-92.en_US
dc.description.abstractBACKGROUND: For dialysis patients with a cancer history, a period of surveillance is generally recommended before listing for transplantation. However, the outcomes of patients with cancer recurrence and/or a second primary cancer after transplantation are unknown. AIM: To determine the prognosis of kidney transplant recipients who developed cancer after transplantation and whether this varied with cancer types (first cancer, recurrence, second primary cancer). METHODS: Using data from the Australian and New Zealand Dialysis and Transplant Registry, we compared the cancer-specific and all-cause mortality among recipients with different cancer types using adjusted Cox proportional hazard models. RESULTS: Of the 21,415 recipients transplanted between 1965 and 2012, 3% (651 of 21,415) had a previous cancer history. A total of 2840 (13%) recipients developed cancer after the first transplant, of whom 2760 (97.2%) developed a first cancer, 23 (0.8%) experienced cancer recurrence, and 57 (2%) developed a second primary cancer. There were no significant differences in the risks of cancer-specific and all-cause mortality between recipients who developed their first cancer after transplant, those with cancer recurrence (adjusted hazard ratios [aHRs], 0.79; 95% confidence interval [95% CI], 0.38-1.67; P = 0.54 and aHRs, 0.86; 95% CI, 0.45-1.66; P = 0.66, respectively) and recipients who developed a second primary cancer after transplantation (aHRs, 1.01; 95%CI, 0.63-1.62; P = 0.95 and aHRs, 1.16; 95% CI, 0.79-1.69; P = 0.45, respectively). CONCLUSION: Among patients with a previous history of malignancy, recurrent and second primary cancers are infrequent after renal transplantation. A history of previous malignancy does not have an additive effect on the cancer-specific and overall survival of kidney transplant recipients who develop cancer.en_US
dc.subjectUroRenal, Vascular Clinical Institute, Epworth HealthCare, Victoria, Australiaen_US
dc.subjectDepartment of Nephrology, Epworth HealthCare, Richmond, Victoria, Australia.en_US
dc.subjectDepartment of Gastroenterology, Epworth HealthCare, Richmond, Victoria, Australia.en_US
dc.subjectKidney Transplantationen_US
dc.subjectTransplant Recipientsen_US
dc.subjectRenal Insufficiencyen_US
dc.subjectKidney Failureen_US
dc.subjectProportional Hazards Modelsen_US
dc.subjectRisk Factorsen_US
dc.subjectAustralian and New Zealand Dialysis and Transplant Registryen_US
dc.titleCancer-specific and all-cause mortality in kidney transplant recipients with and without a prior cancer.en_US
dc.typeJournal Articleen_US
dc.description.affiliatesDepartment of Renal Medicine, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia.en_US
dc.description.affiliatesANZDATA Registry, Royal Adelaide Hospital, Adelaide, South Australia, Australia.en_US
dc.description.affiliatesSchool of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia.en_US
dc.description.affiliatesSydney School of Public Health, University of Sydney, New South Wales, Australia.en_US
dc.description.affiliatesCentre for Kidney Research, The Children's Hospital at Westmead, New South Wales, Australia.en_US
dc.description.affiliatesDepartment of Nephrology, Western Hospital, University of Melbourne, Victoria, Australia.en_US
dc.description.affiliatesNorthwestern Academic Centre, University of Melbourne, Victoria, Australia.en_US
dc.description.affiliatesDepartment of Nephrology, Central Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, South Australia, Australia.en_US
dc.description.affiliatesCentre for Transplant and Renal Research, Westmead Hospital, New South Wales, Australia.en_US
dc.type.studyortrialRetrospective studiesen_US
Appears in Collections:Cancer Services
UroRenal, Vascular

Files in This Item:
There are no files associated with this item.

Items in Epworth are protected by copyright, with all rights reserved, unless otherwise indicated.