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Title: Assessment of optic pathway structure and function in patients with compression of the optic chiasm: a correlation with optical coherence tomography.
Epworth Authors: Phal, Pramit
Kokkinos, Chris
Other Authors: Steward, C.
Nichols, A. D.
Desmond, P. M.
Danesh-Meyer, H.
Sufaro, Y. Z.
Kaye, Andrew
Moffat, B. A.
Keywords: Optical Coherence Tomography
Quantitative OCT
Functional Magnetic Resonance Imaging
Chiasmal Compression
Epworth Medical Imaging, Victoria, Australia
Issue Date: Jul-2016
Publisher: ARVO (Association for Research in Vision and Ophthalmology)
Citation: Invest Ophthalmol Vis Sci. 2016 Jul 1;57(8):3884-90
Abstract: PURPOSE: The purpose of this study was to investigate correlations between retinal fiber thickness measured by optical coherence tomography (OCT) and anterograde functional and structural differences in the optic pathway of patients with compression of the optic chiasm. Our hypothesis was that loss of visual acuity caused by chronic compressive pathologies may lead to an irreversible decline in vision because of permanent neurodegeneration of the optic radiations and visual cortex. METHODS: Quantitative OCT, functional magnetic resonance imaging (MRI) and diffusion tensor MRI measurements were made in 17 patients being surgically treated for chiasmal compression. RESULTS: In our study we found that surgically irreversible visual field defects and reduced retinal nerve fiber layer thickness were significantly associated with lower fractional diffusion anisotropy and higher diffusivities in optic radiations and less functional MRI activation in the visual cortex. CONCLUSIONS: Damage to the retinal nerve fiber layer is associated with downstream structural and functional degradation of the optic pathway. This may be related to trans-synaptic degeneration and the fact that these factors are important potential imaging biomarkers for predicting visual recovery after surgical decompression.
DOI: 10.1167/iovs.15-18734
PubMed URL:
ISSN: 0146-0404
Journal Title: Investigative Ophthalmology and Visual Science
Type: Journal Article
Affiliated Organisations: Department of Radiology, The University of Melbourne, Parkville, Victoria, Australia.
Department of Neurosurgery, Alfred Health, Prahran, Victoria, Australia.
Department of Ophthalmology, The University of Auckland, Auckland, New Zealand.
Department of Neurosurgery, The University of Melbourne, Parkville, Victoria, Australia.
Department of Anatomy and Neuroscience, Melbourne Neuroscience Institute, The University of Melbourne, Parkville, Victoria, Australia.
Type of Clinical Study or Trial: Comparative Study
Appears in Collections:Diagnostic Services

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